Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase, AMP-activated, gamma 1 non-catalytic subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | CBS domain containing protein | protein kinase, AMP-activated, gamma 1 non-catalytic subunit | 340 aa | 312 aa | 23.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0319 | 0.2132 | 0.2132 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0181 | 0 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0319 | 0.2132 | 0.2132 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0319 | 0.2132 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0319 | 0.2132 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0319 | 0.2132 | 0.2132 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0319 | 0.2132 | 0.2132 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0207 | 0.0401 | 0.0401 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0319 | 0.2132 | 0.2132 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0319 | 0.2132 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0319 | 0.2132 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0319 | 0.2132 | 0.2132 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0207 | 0.0401 | 0.1881 |
Loa Loa (eye worm) | aminopeptidase N | 0.0319 | 0.2132 | 0.22 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0181 | 0 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0829 | 1 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0319 | 0.2132 | 0.2132 |
Loa Loa (eye worm) | hypothetical protein | 0.0717 | 0.8269 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.051 | 0.5077 | 0.5943 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0319 | 0.2132 | 0.2132 |
Entamoeba histolytica | aminopeptidase, putative | 0.0319 | 0.2132 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0319 | 0.2132 | 0.2132 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0319 | 0.2132 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0319 | 0.2132 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0622 | 0.6808 | 0.8143 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0181 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0319 | 0.2132 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0319 | 0.2132 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0319 | 0.2132 | 0.2132 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0181 | 0 | 0.5 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0181 | 0 | 0.5 |
Onchocerca volvulus | 0.0829 | 1 | 1 | |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0319 | 0.2132 | 1 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0181 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0319 | 0.2132 | 1 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0181 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0829 | 1 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0319 | 0.2132 | 1 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0319 | 0.2132 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0319 | 0.2132 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 9.9 uM | Activation of recombinant AMPK alpha2beta1gamma1 (unknown origin) after 2 hrs by scintillation proximity assay | ChEMBL. | 24900695 |
Efficacy (binding) | = 227 % | Activation of recombinant AMPK alpha2beta1gamma1 (unknown origin) at 20 ug/mL after 2 hrs by scintillation proximity assay relative to AMP | ChEMBL. | 24900695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.