Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear hormone receptor | 0.2099 | 0.9641 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0437 | 0.0359 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.2099 | 0.9641 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0373 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0437 | 0.0359 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | Antimicrobial activity against benznidazole-resistant epimastigotes of Trypanosoma cruzi Tulahuen 2 assessed as growth inhibition at 25 uM measured on day 5 by spectrophotometry | ChEMBL. | No reference | |
MIC (functional) | = 13.61 ug ml-1 | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate Alamar Blue assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.