Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1185 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1185 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Echinococcus granulosus | cathepsin b | 0.1185 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1185 | 1 | 1 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.0493 | 0.2507 | 0.8379 |
Toxoplasma gondii | cathepsin CPC1 | 0.0493 | 0.2507 | 0.8379 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0627 | 0.3958 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1185 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0434 | 0.1864 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0627 | 0.3958 | 0.3598 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0627 | 0.3958 | 0.3598 |
Onchocerca volvulus | 0.0434 | 0.1864 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.0538 | 0.2992 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0627 | 0.3958 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Echinococcus multilocularis | cathepsin b | 0.1185 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0434 | 0.1864 | 0.1571 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Loa Loa (eye worm) | hypothetical protein | 0.1185 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0627 | 0.3958 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1185 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0434 | 0.1864 | 0.6228 |
Giardia lamblia | Cathepsin B precursor | 0.0538 | 0.2992 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0351 | 0.0974 | 0.2371 |
Brugia malayi | Cathepsin L-like precursor | 0.0434 | 0.1864 | 0.1571 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0627 | 0.3958 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Echinococcus granulosus | cathepsin b | 0.1185 | 1 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0538 | 0.2992 | 0.5389 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0434 | 0.1864 | 0.7433 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0434 | 0.1864 | 0.1571 |
Onchocerca volvulus | 0.0434 | 0.1864 | 1 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0487 | 0.2441 | 0.1992 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0434 | 0.1864 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0627 | 0.3958 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0434 | 0.1864 | 1 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.0493 | 0.2507 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0434 | 0.1864 | 0.1571 |
Plasmodium vivax | vivapain-2 | 0.0434 | 0.1864 | 0.7433 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0434 | 0.1864 | 0.1571 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0627 | 0.3958 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Loa Loa (eye worm) | hypothetical protein | 0.0434 | 0.1864 | 0.1571 |
Onchocerca volvulus | 0.0434 | 0.1864 | 1 | |
Onchocerca volvulus | Cathepsin F homolog | 0.0434 | 0.1864 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0434 | 0.1864 | 0.1571 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.0493 | 0.2507 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Loa Loa (eye worm) | cysteine protease | 0.0434 | 0.1864 | 0.1571 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0434 | 0.1864 | 0.1571 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0493 | 0.2507 | 0.8379 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0493 | 0.2507 | 0.2238 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0627 | 0.3958 | 0.3598 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0434 | 0.1864 | 0.7433 |
Plasmodium vivax | vivapain-2 | 0.0434 | 0.1864 | 0.7433 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0538 | 0.2992 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0627 | 0.3958 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0434 | 0.1864 | 0.1571 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0538 | 0.2992 | 0.274 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0434 | 0.1864 | 0.138 |
Leishmania major | cathepsin L-like protease | 0.0627 | 0.3958 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0434 | 0.1864 | 0.1571 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0627 | 0.3958 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0434 | 0.1864 | 0.1571 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0538 | 0.2992 | 0.2575 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0434 | 0.1864 | 0.7433 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0627 | 0.3958 | 0.3598 |
Giardia lamblia | Cathepsin B precursor | 0.0538 | 0.2992 | 1 |
Toxoplasma gondii | cathepsin B | 0.0538 | 0.2992 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1185 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0434 | 0.1864 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0434 | 0.1864 | 0.1571 |
Loa Loa (eye worm) | cathepsin B | 0.0538 | 0.2992 | 0.274 |
Onchocerca volvulus | Cathepsin L homolog | 0.0434 | 0.1864 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0434 | 0.1864 | 0.1571 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0434 | 0.1864 | 0.1571 |
Echinococcus granulosus | cathepsin l1 | 0.0434 | 0.1864 | 0.1571 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.0493 | 0.2507 | 1 |
Onchocerca volvulus | 0.0434 | 0.1864 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Onchocerca volvulus | 0.0434 | 0.1864 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0434 | 0.1864 | 0.1571 |
Leishmania major | cathepsin L-like protease | 0.0627 | 0.3958 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0627 | 0.3958 | 1 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.0493 | 0.2507 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0627 | 0.3958 | 1 |
Onchocerca volvulus | 0.0434 | 0.1864 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0434 | 0.1864 | 0.5734 |
Leishmania major | cathepsin L-like protease | 0.0627 | 0.3958 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0627 | 0.3958 | 1 |
Onchocerca volvulus | 0.0434 | 0.1864 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0434 | 0.1864 | 0.1571 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 40.18 uM | Inhibition of electric eel AChE using acetylthiocholine as substrate incubated for 20 mins prior to substrate addition measured every 30 secs for 4 mins by Ellman's method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.