Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lactate dehydrogenase C | Starlite/ChEMBL | References |
Homo sapiens | lactate dehydrogenase B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | lactate dehydrogenase, putative | lactate dehydrogenase C | 332 aa | 307 aa | 29.6 % |
Entamoeba histolytica | malate dehydrogenase, putative | lactate dehydrogenase B | 334 aa | 300 aa | 22.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | glycosomal malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Trypanosoma brucei | mitochondrial malate dehydrogenase | 0.0043 | 0 | 0.5 |
Leishmania major | malate dehydrogenase, putative | 0.0111 | 1 | 1 |
Entamoeba histolytica | malate dehydrogenase, putative | 0.0111 | 1 | 1 |
Echinococcus multilocularis | L lactate dehydrogenase | 0.0068 | 0.3641 | 0.3641 |
Trypanosoma brucei | malate dehydrogenase-related | 0.0043 | 0 | 0.5 |
Trypanosoma brucei | cytosolic malate dehydrogenase | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | malate dehydrogenase | 0.0111 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Plasmodium falciparum | L-lactate dehydrogenase | 0.0111 | 1 | 1 |
Trypanosoma cruzi | glycosomal malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Plasmodium falciparum | malate dehydrogenase | 0.0111 | 1 | 1 |
Trypanosoma cruzi | mitochondrial malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Plasmodium vivax | malate dehydrogenase, putative | 0.0111 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Mycobacterium ulcerans | malate dehydrogenase | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | L lactate dehydrogenase | 0.0068 | 0.3641 | 0.3641 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0111 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | lactate dehydrogenase protein | 0.0111 | 1 | 1 |
Schistosoma mansoni | L-lactate dehydrogenase | 0.0111 | 1 | 1 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0111 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Plasmodium vivax | lactate dehydrogenase | 0.0111 | 1 | 1 |
Trypanosoma cruzi | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Toxoplasma gondii | lactate dehydrogenase LDH2 | 0.0111 | 1 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0111 | 1 | 1 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0111 | 1 | 1 |
Echinococcus granulosus | L lactate dehydrogenase B chain | 0.0111 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | L lactate dehydrogenase B chain | 0.0111 | 1 | 1 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0111 | 1 | 1 |
Toxoplasma gondii | malate dehydrogenase MDH | 0.0111 | 1 | 0.5 |
Chlamydia trachomatis | malate dehydrogenase | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE MALATE DEHYDROGENASE MDH | 0.0043 | 0 | 0.5 |
Giardia lamblia | Malate dehydrogenase | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 1 |
Trypanosoma brucei | glycosomal malate dehydrogenase | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | cytosolic malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | malate dehydrogenase | 0.0111 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable malate dehydrogenase Mdh | 0.0043 | 0 | 0.5 |
Toxoplasma gondii | lactate dehydrogenase LDH1 | 0.0111 | 1 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | lactate dehydrogenase protein | 0.0111 | 1 | 1 |
Trypanosoma cruzi | cytosolic malate dehydrogenase, putative | 0.0043 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 uM | Inhibition of human recombinant carboxy-terminal his-tagged LDHA (1 to 331) expressed in Escherichia coli using pyruvate as substrate assessed as disappearance of NADH after 10 mins by fluorescence assay | ChEMBL. | 24012183 |
IC50 (binding) | = 7 uM | Inhibition of human recombinant carboxy-terminal his-tagged LDHB (1 to 333) expressed in Escherichia coli using pyruvate as substrate assessed as disappearance of NADH after 10 mins by fluorescence assay | ChEMBL. | 24012183 |
Kd (binding) | = 3 uM | Binding affinity to human recombinant carboxy-terminal his-tagged LDHA (1 to 331) expressed in Escherichia coli by surface plasmon resonance analysis in presence of NADH | ChEMBL. | 24012183 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.