Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | adenosine kinase | 0.0084 | 0 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.0084 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0527 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein | 0.0527 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0527 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0527 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0527 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein | 0.0527 | 1 | 1 |
Schistosoma mansoni | adenosine kinase | 0.0084 | 0 | 0.5 |
Brugia malayi | Adenosine kinase-like | 0.0084 | 0 | 0.5 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0084 | 0 | 0.5 |
Trypanosoma brucei | nucleoside 2-deoxyribosyltransferase | 0.0527 | 1 | 1 |
Echinococcus granulosus | adenosine kinase | 0.0084 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 2 | Antimaximal electroshock seizure (MES) activity in mice after peroral administration of 100 mg/kg of compound; 2/5 | ChEMBL. | 2891853 |
Inhibition (functional) | < 30 % | Antiexploratory activity (EXPL) of mice determined by an antimex activity meter, 100 mg/kg of dose was administered perorally; No inhibition | ChEMBL. | 2891853 |
Inhibition (functional) | < 30 % | Antireserpine activity (RES) of mice after peroral administration of 100 mg/kg of compound; No inhibition | ChEMBL. | 2891853 |
Inhibition (functional) | < 30 % | Antitremorine activity(TRM) of mice after peroral administration of 100 mg/kg of compound; No inhibition | ChEMBL. | 2891853 |
Inhibition (functional) | < 30 % | Antiexploratory activity (EXPL) of mice determined by an antimex activity meter, 100 mg/kg of dose was administered perorally; No inhibition | ChEMBL. | 2891853 |
Inhibition (functional) | < 30 % | Antireserpine activity (RES) of mice after peroral administration of 100 mg/kg of compound; No inhibition | ChEMBL. | 2891853 |
Inhibition (functional) | < 30 % | Antitremorine activity(TRM) of mice after peroral administration of 100 mg/kg of compound; No inhibition | ChEMBL. | 2891853 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.