Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | regulator of G protein signaling | 0.0226 | 0.0319 | 0.0319 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0226 | 0.0319 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0226 | 0.0319 | 0.0319 |
Echinococcus granulosus | axis inhibition protein axin | 0.0226 | 0.0319 | 0.0358 |
Schistosoma mansoni | regulator of G protein signaling | 0.0226 | 0.0319 | 0.0319 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0226 | 0.0319 | 0.0358 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0232 | 0.0345 | 0.0345 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0226 | 0.0319 | 0.0358 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0232 | 0.0345 | 0.0387 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.204 | 0.8927 | 1 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.204 | 0.8927 | 0.8892 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.204 | 0.8927 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0226 | 0.0319 | 0.5 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.2267 | 1 | 1 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0232 | 0.0345 | 0.0387 |
Schistosoma mansoni | regulator of G protein signaling | 0.0226 | 0.0319 | 0.0319 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2267 | 1 | 1 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0226 | 0.0319 | 0.0358 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.204 | 0.8927 | 0.8892 |
Echinococcus multilocularis | expressed protein | 0.0226 | 0.0319 | 0.0358 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0226 | 0.0319 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0226 | 0.0319 | 0.5 |
Echinococcus granulosus | expressed protein | 0.0226 | 0.0319 | 0.0358 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0226 | 0.0319 | 0.0358 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0226 | 0.0319 | 0.0319 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0226 | 0.0319 | 0.0358 |
Echinococcus granulosus | axis inhibition protein axin | 0.0226 | 0.0319 | 0.0358 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0226 | 0.0319 | 0.0358 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0226 | 0.0319 | 0.0358 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.204 | 0.8927 | 0.8892 |
Schistosoma mansoni | axis inhibition protein axin | 0.0226 | 0.0319 | 0.0319 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0226 | 0.0319 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0226 | 0.0319 | 0.0319 |
Schistosoma mansoni | regulator of G protein signaling | 0.0226 | 0.0319 | 0.0319 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0226 | 0.0319 | 0.0319 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0226 | 0.0319 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0232 | 0.0345 | 0.0345 |
Entamoeba histolytica | hypothetical protein | 0.0226 | 0.0319 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0226 | 0.0319 | 0.0358 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0226 | 0.0319 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0226 | 0.0319 | 0.0358 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0226 | 0.0319 | 0.0358 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0226 | 0.0319 | 0.0358 |
Schistosoma mansoni | regulator of G protein signaling | 0.0226 | 0.0319 | 0.0319 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0226 | 0.0319 | 0.0358 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0232 | 0.0345 | 0.0027 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0226 | 0.0319 | 0.0358 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0226 | 0.0319 | 0.0358 |
Schistosoma mansoni | axis inhibition protein axin | 0.0226 | 0.0319 | 0.0319 |
Entamoeba histolytica | hypothetical protein | 0.0226 | 0.0319 | 0.5 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0226 | 0.0319 | 0.5 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0226 | 0.0319 | 0.0358 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | > 80 % | Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production at 50 uM after 24 hrs by Griess assay relative to control | ChEMBL. | 24042007 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.