Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, delta 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | CoRest homolog | 0.0526 | 0.8265 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 0.8024 | 0.9708 |
Loa Loa (eye worm) | hypothetical protein | 0.0526 | 0.8265 | 1 |
Plasmodium vivax | hypothetical protein | 0.0015 | 0 | 0.5 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0511 | 0.8024 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0634 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0015 | 0 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ke (binding) | = 0.23 nM | Ability to displace DPDPE from human recombinant Opioid receptor delta 1 in CHO cells using [35S]- GTPgama S Assay | ChEMBL. | 12519069 |
Ke (binding) | = 0.23 nM | Ability to displace DPDPE from human recombinant Opioid receptor delta 1 in CHO cells using [35S]- GTPgama S Assay | ChEMBL. | 12519069 |
Ke (binding) | = 0.46 nM | Ability to displace U-69,593 from human recombinant Opioid receptor kappa 1 in CHO cells using [35S]- GTPgama S Assay | ChEMBL. | 12519069 |
Ke (binding) | = 0.46 nM | Ability to displace U-69,593 from human recombinant Opioid receptor kappa 1 in CHO cells using [35S]- GTPgama S Assay | ChEMBL. | 12519069 |
Ke (binding) | = 3.37 nM | Ability to displace DAMGO from human recombinant Opioid receptor mu 1 in CHO cells using [35S]- GTPgama S Assay | ChEMBL. | 12519069 |
Ke (binding) | = 3.37 nM | Ability to displace DAMGO from human recombinant Opioid receptor mu 1 in CHO cells using [35S]- GTPgama S Assay | ChEMBL. | 12519069 |
Ki (binding) | = 0.68 nM | Ability to displace [3H]-U69,593 from human recombinant Opioid receptor kappa 1 in CHO cells | ChEMBL. | 12519069 |
Ki (binding) | = 0.68 nM | Ability to displace [3H]-U69,593 from human recombinant Opioid receptor kappa 1 in CHO cells | ChEMBL. | 12519069 |
Ki (binding) | = 7.67 nM | Ability to displace [3H]-DPDPE from human recombinant Opioid receptor delta 1 in CHO cells | ChEMBL. | 12519069 |
Ki (binding) | = 7.67 nM | Ability to displace [3H]-DPDPE from human recombinant Opioid receptor delta 1 in CHO cells | ChEMBL. | 12519069 |
Ki (binding) | = 31.59 nM | Ability to displace [3H]-DAMGO from human recombinant Opioid receptor mu 1 in CHO cells | ChEMBL. | 12519069 |
Ki (binding) | = 31.59 nM | Ability to displace [3H]-DAMGO from human recombinant Opioid receptor mu 1 in CHO cells | ChEMBL. | 12519069 |
Ratio (binding) | = 0.5 | Selectivity between delta receptor and kappa receptor | ChEMBL. | 12519069 |
Ratio (binding) | = 7 | Selectivity between mu receptor and kappa receptor | ChEMBL. | 12519069 |
Ratio (binding) | = 11 | Selectivity between delta receptor and kappa receptor | ChEMBL. | 12519069 |
Ratio (binding) | = 46 | Selectivity between mu receptor and kappa receptor | ChEMBL. | 12519069 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.