Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0098 | 0.0006 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0098 | 0.0006 | 1 |
Brugia malayi | protein kinase C3,putative | 0.1017 | 0.2441 | 0.2437 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.1086 | 0.2625 | 0.2621 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.3868 | 1 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.1113 | 0.2695 | 0.2691 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.3868 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.3868 | 1 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.3868 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3868 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0098 | 0.0006 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0098 | 0.0006 | 1 |
Brugia malayi | protein kinase C II. | 0.0167 | 0.0189 | 0.0184 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0167 | 0.0189 | 0.0184 |
Trichomonas vaginalis | AGC family protein kinase | 0.0098 | 0.0006 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0167 | 0.0189 | 0.0184 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.3868 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0098 | 0.0006 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0098 | 0.0006 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.3868 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0098 | 0.0006 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0098 | 0.0006 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0167 | 0.0189 | 0.0184 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.1568 | 0.3904 | 0.39 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0167 | 0.0189 | 0.0184 |
Trichomonas vaginalis | AGC family protein kinase | 0.0098 | 0.0006 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.3868 | 1 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0167 | 0.0189 | 0.0184 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0098 | 0.0006 | 0.5 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.23 | 0.5842 | 0.584 |
Toxoplasma gondii | AGC kinase | 0.0098 | 0.0006 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0098 | 0.0006 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0167 | 0.0189 | 0.0184 |
Trichomonas vaginalis | AGC family protein kinase | 0.0098 | 0.0006 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.1182 | 0.2879 | 0.2875 |
Entamoeba histolytica | protein kinase, putative | 0.0098 | 0.0006 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0098 | 0.0006 | 0.5 |
Echinococcus granulosus | protein kinase c iota type | 0.1113 | 0.2695 | 0.2691 |
Onchocerca volvulus | 0.3868 | 1 | 0.5 | |
Echinococcus granulosus | protein kinase c epsilon type | 0.0167 | 0.0189 | 0.0184 |
Trichomonas vaginalis | AGC family protein kinase | 0.0098 | 0.0006 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0167 | 0.0189 | 0.0184 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 0.42 uM | Cytotoxicity against Homo sapiens (human) HEK293 cells assessed as inhibition of cell proliferation after 24 hr by MTT assay | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.