Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0132 | 0.0605 | 0.0675 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0132 | 0.0605 | 0.0675 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0132 | 0.0605 | 0.0675 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0132 | 0.0605 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0132 | 0.0605 | 0.0675 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0132 | 0.0605 | 0.0675 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0132 | 0.0605 | 0.5 |
Schistosoma mansoni | axis inhibition protein axin | 0.0132 | 0.0605 | 0.0605 |
Entamoeba histolytica | hypothetical protein | 0.0132 | 0.0605 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0132 | 0.0605 | 0.0675 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0132 | 0.0605 | 0.0675 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0135 | 0.063 | 0.0027 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0132 | 0.0605 | 0.0675 |
Schistosoma mansoni | regulator of G protein signaling | 0.0132 | 0.0605 | 0.0605 |
Schistosoma mansoni | axis inhibition protein axin | 0.0132 | 0.0605 | 0.0605 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1191 | 0.8959 | 0.8892 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0132 | 0.0605 | 0.0675 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0132 | 0.0605 | 0.0675 |
Echinococcus granulosus | axis inhibition protein axin | 0.0132 | 0.0605 | 0.0675 |
Entamoeba histolytica | hypothetical protein | 0.0132 | 0.0605 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0135 | 0.063 | 0.063 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0132 | 0.0605 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0132 | 0.0605 | 0.0605 |
Schistosoma mansoni | regulator of G protein signaling | 0.0132 | 0.0605 | 0.0605 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0132 | 0.0605 | 0.0605 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0132 | 0.0605 | 0.5 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1191 | 0.8959 | 0.8892 |
Echinococcus multilocularis | expressed protein | 0.0132 | 0.0605 | 0.0675 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0132 | 0.0605 | 0.0675 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1323 | 1 | 1 |
Schistosoma mansoni | regulator of G protein signaling | 0.0132 | 0.0605 | 0.0605 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1323 | 1 | 1 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0135 | 0.063 | 0.0703 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0132 | 0.0605 | 0.0675 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0132 | 0.0605 | 0.0605 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0132 | 0.0605 | 0.0675 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0132 | 0.0605 | 0.5 |
Echinococcus granulosus | expressed protein | 0.0132 | 0.0605 | 0.0675 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0132 | 0.0605 | 0.5 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0132 | 0.0605 | 0.0675 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0135 | 0.063 | 0.063 |
Schistosoma mansoni | regulator of G protein signaling | 0.0132 | 0.0605 | 0.0605 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0132 | 0.0605 | 0.0675 |
Echinococcus granulosus | axis inhibition protein axin | 0.0132 | 0.0605 | 0.0675 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0132 | 0.0605 | 0.0605 |
Schistosoma mansoni | regulator of G protein signaling | 0.0132 | 0.0605 | 0.0605 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0132 | 0.0605 | 0.5 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1191 | 0.8959 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0132 | 0.0605 | 0.5 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1191 | 0.8959 | 0.8892 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1191 | 0.8959 | 1 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0135 | 0.063 | 0.0703 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 9 mm | Antifungal activity against Saccharomyces cerevisiae at 2 to 64 ug/ml after 7 days by agar well diffusion method | ChEMBL. | No reference |
IZ (functional) | = 12 mm | Antifungal activity against Candida albicans at 2 to 64 ug/ml after 7 days by agar well diffusion method | ChEMBL. | No reference |
IZ (functional) | = 12 mm | Antibacterial activity against Escherichia coli at 2 to 64 ug/ml after 24 hr by agar well diffusion method | ChEMBL. | No reference |
MIC (functional) | = 2 ug ml-1 | Antifungal activity against Candida albicans after 7 days by agar well diffusion method | ChEMBL. | No reference |
MIC (functional) | = 6 ug ml-1 | Antifungal activity against Saccharomyces cerevisiae after 7 days by agar well diffusion method | ChEMBL. | No reference |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against Escherichia coli after 24 hr by agar well diffusion method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.