Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.0326 | 0.1221 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0151 | 0.0568 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0255 | 0.2667 | 0.2667 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0152 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.0326 | 0.1127 | |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0152 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0151 | 0.0568 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0378 | 0.1395 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0035 | 0.0326 | 0.1202 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0523 | 0.1928 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0259 | 0.2711 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0033 | 0.0312 | 0.117 |
Entamoeba histolytica | ankyrin repeat protein | 0.0004 | 0 | 0.5 |
Onchocerca volvulus | 0.0276 | 0.289 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.0255 | 0.2667 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0152 | 0.0152 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0152 | 0.0569 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.0255 | 0.2667 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0151 | 0.0568 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.2667 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.2055 | 0.7579 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0151 | 0.0568 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0574 | 0.215 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0378 | 0.1418 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0151 | 0.0151 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0574 | 0.215 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0255 | 0.2667 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0523 | 0.0523 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0152 | 0.0152 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0035 | 0.0326 | 0.0326 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0152 | 0.0152 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0151 | 0.0151 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0152 | 0.0569 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0523 | 0.1928 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0151 | 0.0558 |
Plasmodium vivax | SET domain protein, putative | 0.0035 | 0.0326 | 1 |
Giardia lamblia | Kinase, NEK | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0151 | 0.0151 |
Brugia malayi | Pre-SET motif family protein | 0.0242 | 0.2534 | 0.95 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0523 | 0.1959 |
Giardia lamblia | Protein 21.1 | 0.0004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0574 | 0.215 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0152 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0523 | 0.1959 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0242 | 0.2534 | 0.95 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0151 | 0.0558 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0574 | 0.215 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0152 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0151 | 0.0558 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0035 | 0.0326 | 0.0326 |
Trichomonas vaginalis | set domain proteins, putative | 0.0276 | 0.289 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0.0152 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0151 | 0.0568 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0326 | 0.1202 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0523 | 0.1959 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0523 | 0.1959 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0523 | 0.1928 |
Entamoeba histolytica | protein kinase, putative | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0326 | 0.1202 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.2667 | 1 |
Echinococcus granulosus | geminin | 0.0197 | 0.2055 | 0.7704 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0152 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0.0152 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0151 | 0.0568 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0035 | 0.0326 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0152 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0326 | 0.1202 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0151 | 0.0558 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0523 | 0.0523 |
Echinococcus multilocularis | geminin | 0.0197 | 0.2055 | 0.2055 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.2055 | 0.7579 |
Brugia malayi | Pre-SET motif family protein | 0.0035 | 0.0326 | 0.1221 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0152 | 0.0569 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0378 | 0.1418 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0151 | 0.0568 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0326 | 0.1221 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0152 | 0.0569 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0152 | 0.056 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 96 % | Antitubercular activity against Mycobacterium tuberculosis H37Rv MTCC 200 assessed as growth inhibition at MIC by L.J. MIC method | ChEMBL. | No reference |
Inhibition (functional) | = 98 % | Antitubercular activity against Mycobacterium tuberculosis H37Rv MTCC 200 assessed as growth inhibition at 6.25 ug/ml by BACTEC MGIT method | ChEMBL. | No reference |
MIC (functional) | = 0.061 ug ml-1 | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of complete maturation into schizonts after 40 hr | ChEMBL. | No reference |
MIC (functional) | > 6.25 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv MTCC 200 assessed as growth inhibition by BACTEC MGIT method | ChEMBL. | No reference |
MIC (functional) | = 100 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv MTCC 200 assessed as growth inhibition by L.J. MIC method | ChEMBL. | No reference |
MIC99 (functional) | = 500 ug ml-1 | Antimicrobial activity against Escherichia coli MTCC 443 assessed as growth inhibition by broth microdilution method | ChEMBL. | No reference |
MIC99 (functional) | > 1000 ug ml-1 | Antimicrobial activity against Candida albicans MTCC 227 assessed as growth inhibition by broth microdilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.