Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, shaker-related subfamily, member 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | voltage gated potassium channel | potassium voltage-gated channel, shaker-related subfamily, member 5 | 613 aa | 521 aa | 34.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0104 | 0.1662 | 0.1662 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0104 | 0.1662 | 0.1662 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0361 | 0.9363 | 0.9363 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0155 | 0.3194 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0361 | 0.9363 | 0.9363 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.3903 | 0.3903 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 1 | 1 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0382 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0104 | 0.1662 | 0.1662 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.0382 | 1 | 1 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0382 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0104 | 0.1662 | 0.1662 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0104 | 0.1662 | 0.1662 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.0382 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.3903 | 0.3903 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.0382 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1662 | 0.1662 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0099 | 0.1526 | 0.1526 |
Echinococcus granulosus | geminin | 0.0179 | 0.3903 | 0.3903 |
Echinococcus multilocularis | geminin | 0.0179 | 0.3903 | 0.3903 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0382 | 1 | 1 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0382 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0104 | 0.1662 | 0.1662 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.21 uM | Inhibition of human Kv1.5 channel expressed in HEK293 cells by whole cell patch clamp technique | ChEMBL. | 24071446 |
Inhibition (binding) | Inhibition of human Kv1.5 channel expressed in HEK293 cells by whole cell patch clamp technique | ChEMBL. | 24071446 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.