Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Pim-1 proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | References |
Homo sapiens | Pim-2 proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | protein lipid droplet kinase (LDK) | Pim-2 proto-oncogene, serine/threonine kinase | 311 aa | 278 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.1792 | 1 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.112 | 0.5018 | 0.3471 |
Brugia malayi | Casein kinase II, alpha chain | 0.0764 | 0.237 | 0.0178 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0764 | 0.237 | 0.5 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0764 | 0.237 | 0.5 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.1792 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1792 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0764 | 0.237 | 0.5 |
Trypanosoma cruzi | casein kinase II, putative | 0.0764 | 0.237 | 0.5 |
Leishmania major | casein kinase II, putative | 0.0764 | 0.237 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0764 | 0.237 | 0.237 |
Onchocerca volvulus | 0.1191 | 0.5543 | 0.4581 | |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.1792 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.1792 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.1792 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0764 | 0.237 | 0.0724 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.1191 | 0.5543 | 0.4581 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0764 | 0.237 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0764 | 0.237 | 0.5 |
Entamoeba histolytica | casein kinase, putative | 0.0764 | 0.237 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0745 | 0.2232 | 0.0556 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0764 | 0.237 | 0.5 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0764 | 0.237 | 0.5 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.1792 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0764 | 0.237 | 0.5 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0764 | 0.237 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0764 | 0.237 | 0.5 |
Trypanosoma brucei | Casein kinase II | 0.0764 | 0.237 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0764 | 0.237 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.112 | 0.5018 | 0.3471 |
Plasmodium vivax | unspecified product | 0.0764 | 0.237 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0764 | 0.237 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 25 nM | Inhibition of Pim1 (unknown origin) using STK3 as substrate preincubated for 30 mins followed by substrate and ATP addition after 45 mins by HTRF assay | ChEMBL. | 24091081 |
IC50 (binding) | = 781 nM | Inhibition of Pim2 (unknown origin) using STK1 as substrate preincubated for 30 mins followed by substrate and ATP addition after 60 mins by HTRF assay | ChEMBL. | 24091081 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.