Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.0059 | 0.0066 |
Echinococcus granulosus | intestinal type alkaline phosphatase | 0.0159 | 0.1183 | 0.1331 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0762 | 1 | 1 |
Echinococcus granulosus | alkaline phosphatase | 0.0159 | 0.1183 | 0.1331 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.0686 | 0.8889 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0059 | 0.0059 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.0059 | 0.0066 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.0059 | 0.0066 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0762 | 1 | 1 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0159 | 0.1183 | 0.1331 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.0059 | 0.0066 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0159 | 0.1183 | 0.1331 |
Schistosoma mansoni | alkaline phosphatase | 0.0159 | 0.1183 | 0.1183 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.0059 | 0.0066 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.0059 | 0.0059 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.0059 | 0.0059 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.0059 | 0.0066 |
Schistosoma mansoni | alkaline phosphatase | 0.0159 | 0.1183 | 0.1183 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.0059 | 0.0059 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0686 | 0.8889 | 0.8882 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0159 | 0.1183 | 0.1331 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.0686 | 0.8889 | 0.8889 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0059 | 0.0059 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.0686 | 0.8889 | 1 |
Echinococcus multilocularis | alkaline phosphatase | 0.0159 | 0.1183 | 0.1331 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0159 | 0.1183 | 0.1331 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0159 | 0.1183 | 0.1331 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0686 | 0.8889 | 0.8889 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 521.34 nM | Binding affinity to acetylcholinesterase (unknown origin) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.