Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | epidermal growth factor receptor | 0.0145 | 0.0633 | 0.0633 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.1628 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.0204 | 0.0195 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0046 | 0.0009 | 0.0009 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.0209 | 0.02 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0078 | 0.0209 | 0.02 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0078 | 0.0209 | 0.0209 |
Schistosoma mansoni | protein kinase | 0.1628 | 1 | 1 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.1628 | 1 | 1 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.1628 | 1 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0145 | 0.0633 | 0.0625 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.1628 | 1 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0046 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0145 | 0.0633 | 0.0625 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0145 | 0.0633 | 0.0625 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0078 | 0.0209 | 0.02 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.0209 | 0.02 |
Schistosoma mansoni | tyrosine kinase | 0.0145 | 0.0633 | 0.0625 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.0204 | 0.0195 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.0204 | 0.0195 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against Escherichia coli expressing TolC mutant | ChEMBL. | 24112046 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.