Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | protein kinase, putative | 0.0024 | 0.0011 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0024 | 0.0011 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0024 | 0.0014 | 1 |
Trypanosoma brucei | STE/STE11 serine/threonine-protein kinase, putative | 0.0024 | 0.0011 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0024 | 0.0014 | 1 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Echinococcus granulosus | activin receptor type | 0.0024 | 0.0011 | 0.0011 |
Schistosoma mansoni | protein kinase | 0.3836 | 1 | 1 |
Toxoplasma gondii | calcium dependent protein kinase CDPK8 | 0.0024 | 0.0011 | 0.5 |
Echinococcus multilocularis | activin receptor type | 0.0024 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.3836 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0034 | 0.0038 | 0.0038 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.3836 | 1 | 1 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Schistosoma mansoni | protein kinase | 0.0024 | 0.0011 | 0.0011 |
Schistosoma mansoni | protein kinase | 0.0024 | 0.0011 | 0.0011 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.3836 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0024 | 0.0011 | 0.8262 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Schistosoma mansoni | protein kinase | 0.0024 | 0.0011 | 0.0011 |
Plasmodium falciparum | protein kinase, putative | 0.0024 | 0.0011 | 0.5 |
Echinococcus granulosus | dual specificity testis-specific protein kinase | 0.0024 | 0.0011 | 0.0011 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0024 | 0.0011 | 0.5 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.3836 | 1 | 1 |
Leishmania major | protein kinase, putative | 0.0024 | 0.0011 | 0.5 |
Echinococcus multilocularis | dual specificity testis specific protein kinase | 0.0024 | 0.0011 | 0.0011 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 12.5 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 24 hrs by agar microdilution method | ChEMBL. | 24900592 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.