Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04224 tachykinin receptor 3, putative | Get druggable targets OG5_137770 | All targets in OG5_137770 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.0163 | 0.0195 | 0.0195 |
Echinococcus multilocularis | dihydrofolate reductase | 0.667 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.667 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3948 | 0.5899 | 0.5 |
Onchocerca volvulus | 0.1117 | 0.1632 | 0.5 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3948 | 0.5899 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1117 | 0.1632 | 0.0954 |
Brugia malayi | hypothetical protein | 0.0531 | 0.075 | 0.075 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.0007 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0163 | 0.0195 | 0.0188 |
Brugia malayi | Dihydrofolate reductase | 0.667 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1117 | 0.1632 | 0.1626 |
Echinococcus multilocularis | thymidylate synthase | 0.1117 | 0.1632 | 0.1626 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3948 | 0.5899 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.667 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.1117 | 0.1632 | 0.1632 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3948 | 0.5899 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.0038 | 0.0007 | 0.0000022548 |
Chlamydia trachomatis | dihydrofolate reductase | 0.667 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.667 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3948 | 0.5899 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3948 | 0.5899 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.1117 | 0.1632 | 0.1626 |
Echinococcus granulosus | dihydrofolate reductase | 0.667 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0163 | 0.0195 | 0.0195 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0038 | 0.0007 | 0.0000022548 |
Schistosoma mansoni | dihydrofolate reductase | 0.667 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0531 | 0.075 | 0.5 |
Brugia malayi | thymidylate synthase | 0.1117 | 0.1632 | 0.1632 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.0007 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.667 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.61 nM | Antagonist activity at NK1 receptor (unknown origin) | ChEMBL. | 24075145 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.