Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | potassium inwardly-rectifying channel, subfamily J, member 1 | Starlite/ChEMBL | References |
Rattus norvegicus | ATP-sensitive inward rectifier potassium channel 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | ATP-sensitive inward rectifier potassium channel 1 | 391 aa | 333 aa | 38.4 % | |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | ATP-sensitive inward rectifier potassium channel 1 | 391 aa | 329 aa | 38.9 % |
Onchocerca volvulus | ATP-sensitive inward rectifier potassium channel 1 | 391 aa | 332 aa | 44.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.021 | 0.021 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.168 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.021 | 0.1145 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.183 | 0.183 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2039 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.021 | 0.1028 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.021 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0204 | 1 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.168 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.2039 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0204 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.021 | 0.1145 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.183 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.021 | 0.1028 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.021 | 0.1145 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.021 | 0.1145 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.183 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1529 | 0.1529 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.183 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.072 uM | Inhibition of human ROMK channel by electrophysiology assay | ChEMBL. | 24075732 |
IC50 (binding) | = 0.072 uM | Inhibition of human ROMK expressed in CHO cells by whole-cell voltage clamp method | ChEMBL. | 27017115 |
IC50 (binding) | = 0.19 uM | Inhibition of human ROMK channel-mediated 86Rb+ flux expressed in CHO cells after 35 mins by scintillation counting analysis | ChEMBL. | 24075732 |
IC50 (binding) | = 0.19 uM | Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by [86Rb+] flux functional assay | ChEMBL. | 27017115 |
IC50 (binding) | = 13 uM | Inhibition of human ERG by electrophysiology assay | ChEMBL. | 24075732 |
IC50 (binding) | = 13 uM | Inhibition of human ERG by electrophysiology analysis | ChEMBL. | 27017115 |
IC50 (binding) | = 20 uM | Displacement of [35S]-MK499 from human ERG | ChEMBL. | 24075732 |
IC50 (binding) | = 20 uM | Displacement of [35S]-MK499 from human ERG expressed in HEK293 cells | ChEMBL. | 27017115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.