TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 466.92 | Formula: C23H23ClN6O3
H donors: 0 H acceptors: 5 LogP: 2.44 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CCN(CC1)CCc1cc(Cl)c2c(c1)COC2=O)Cc1ccc(cc1)n1cnnn1
InChi: 1S/C23H23ClN6O3/c24-20-12-17(11-18-14-33-23(32)22(18)20)5-6-28-7-9-29(10-8-28)21(31)13-16-1-3-19(4-2-16)30-15-25-26-27-30/h1-4,11-12,15H,5-10,13-14H2
InChiKey: LXARJHMGHFCGNE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References
Homo sapiens	potassium inwardly-rectifying channel, subfamily J, member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Echinococcus granulosus	rhodopsin orphan GPCR	0.0081	0.7712	1
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0013	0.0439	0.0569
Brugia malayi	Melatonin receptor type 1A	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Schistosoma mansoni	hypothetical protein	0.0081	0.7712	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Echinococcus granulosus	hypothetical protein	0.0081	0.7712	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0081	0.7712	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0081	0.7712	0.7712
Echinococcus granulosus	7TM GPCR rhodopsin	0.0081	0.7712	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0081	0.7712	0.7712
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Schistosoma mansoni	neuropeptide receptor	0.0081	0.7712	1
Schistosoma mansoni	neuropeptide receptor	0.0081	0.7712	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Echinococcus granulosus	somatostatin receptor	0.0081	0.7712	1
Echinococcus granulosus	g protein coupled receptor	0.0081	0.7712	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0081	0.7712	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0081	0.7712	0.7712
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.4272	0.5539
Echinococcus granulosus	rhodopsin orphan GPCR	0.0081	0.7712	1
Brugia malayi	hypothetical protein	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Onchocerca volvulus		0.0081	0.7712	0.5
Brugia malayi	sulfakinin receptor protein	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0081	0.7712	1
Onchocerca volvulus		0.0081	0.7712	0.5
Echinococcus granulosus	orexin receptor type 2	0.0081	0.7712	1
Schistosoma mansoni	biogenic amine receptor	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Loa Loa (eye worm)	hypothetical protein	0.0102	1	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Echinococcus granulosus	G protein coupled receptor 139	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Echinococcus granulosus	neuropeptides capa receptor	0.0081	0.7712	1
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0102	1	1
Toxoplasma gondii	hypothetical protein	0.0102	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3202	0.3202
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0081	0.7712	1
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0439	0.0569
Echinococcus multilocularis	neuropeptides capa receptor	0.0081	0.7712	1
Schistosoma mansoni	hypothetical protein	0.0081	0.7712	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0081	0.7712	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Schistosoma mansoni	neuropeptide f receptor 76f	0.0081	0.7712	1
Schistosoma mansoni	amine GPCR	0.0081	0.7712	1
Brugia malayi	hypothetical protein	0.0081	0.7712	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0081	0.7712	1
Schistosoma mansoni	opsin-like receptor	0.0081	0.7712	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0081	0.7712	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.3518	1
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0439	0.0569
Brugia malayi	RE15519p	0.0081	0.7712	1
Echinococcus multilocularis	g protein coupled receptor	0.0081	0.7712	1
Echinococcus multilocularis	neuropeptide s receptor	0.0081	0.7712	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0081	0.7712	1
Onchocerca volvulus		0.0081	0.7712	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0081	0.7712	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0081	0.7712	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0081	0.7712	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.3833	0.497
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0081	0.7712	1
Schistosoma mansoni	amine GPCR	0.0081	0.7712	1
Brugia malayi	neuropeptide F receptor	0.0081	0.7712	1
Echinococcus multilocularis	somatostatin receptor	0.0081	0.7712	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0081	0.7712	1
Schistosoma mansoni	amine GPCR	0.0081	0.7712	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0081	0.7712	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0081	0.7712	1
Onchocerca volvulus		0.0081	0.7712	0.5
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0081	0.7712	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0081	0.7712	0.7712
Onchocerca volvulus		0.0081	0.7712	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0081	0.7712	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0081	0.7712	0.5
Echinococcus granulosus	fmrfamide receptor	0.0081	0.7712	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0081	0.7712	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0081	0.7712	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0081	0.7712	1
Onchocerca volvulus		0.0081	0.7712	0.5
Onchocerca volvulus		0.0081	0.7712	0.5
Schistosoma mansoni	opsin-like receptor	0.0081	0.7712	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0081	0.7712	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0081	0.7712	1
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.4272	0.5539
Brugia malayi	ORL1-like opioid receptor	0.0081	0.7712	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0081	0.7712	1
Brugia malayi	Serotonin receptor	0.0081	0.7712	1
Onchocerca volvulus		0.0081	0.7712	0.5
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Onchocerca volvulus		0.0081	0.7712	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0081	0.7712	1
Echinococcus granulosus	g-protein coupled receptor	0.0081	0.7712	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0081	0.7712	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0081	0.7712	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0081	0.7712	1
Brugia malayi	Dopamine receptor	0.0081	0.7712	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0081	0.7712	0.7712
Brugia malayi	hypothetical protein	0.0081	0.7712	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Echinococcus granulosus	allatostatin A receptor	0.0081	0.7712	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0081	0.7712	0.7712
Brugia malayi	G-protein coupled receptor	0.0081	0.7712	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0081	0.7712	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0081	0.7712	1
Loa Loa (eye worm)	TYRA-2 protein	0.0081	0.7712	0.7712
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.3833	0.3833
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0081	0.7712	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Onchocerca volvulus		0.0081	0.7712	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0081	0.7712	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.3833	0.497
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Echinococcus multilocularis	sex peptide receptor	0.0081	0.7712	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0081	0.7712	1
Onchocerca volvulus		0.0081	0.7712	0.5
Brugia malayi	Serotonin receptor	0.0081	0.7712	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Loa Loa (eye worm)	neuropeptide F receptor	0.0081	0.7712	0.7712
Echinococcus granulosus	neuropeptide Y receptor	0.0081	0.7712	1
Schistosoma mansoni	amine GPCR	0.0081	0.7712	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0102	1	1
Echinococcus granulosus	neuropeptide receptor	0.0081	0.7712	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0013	0.0439	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Echinococcus granulosus	rhodopsin orphan GPCR	0.0081	0.7712	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0081	0.7712	1
Schistosoma mansoni	neuropeptide receptor	0.0081	0.7712	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0081	0.7712	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0081	0.7712	0.5
Echinococcus granulosus	sex peptide receptor	0.0081	0.7712	1
Echinococcus multilocularis	orexin receptor type 2	0.0081	0.7712	1
Schistosoma mansoni	adenoreceptor	0.0081	0.7712	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0081	0.7712	1
Schistosoma mansoni	hypothetical protein	0.0081	0.7712	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0081	0.7712	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0081	0.7712	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0081	0.7712	1
Echinococcus multilocularis	g protein coupled receptor	0.0081	0.7712	1
Echinococcus multilocularis	fmrfamide receptor	0.0081	0.7712	1
Echinococcus granulosus	neuropeptide Y receptor	0.0081	0.7712	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0081	0.7712	1
Echinococcus multilocularis	g-protein coupled receptor	0.0081	0.7712	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0081	0.7712	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0081	0.7712	1
Brugia malayi	hypothetical protein	0.0081	0.7712	1
Brugia malayi	AKH receptor	0.0081	0.7712	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Brugia malayi	follicle stimulating hormone receptor	0.0081	0.7712	1
Onchocerca volvulus		0.0081	0.7712	0.5
Onchocerca volvulus		0.0081	0.7712	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0081	0.7712	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0081	0.7712	1
Echinococcus granulosus	g protein coupled receptor	0.0081	0.7712	1
Echinococcus multilocularis	neuropeptide receptor	0.0081	0.7712	1
Schistosoma mansoni	biogenic amine receptor	0.0081	0.7712	1
Echinococcus multilocularis	serotonin receptor	0.0081	0.7712	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0439	0.0439
Echinococcus granulosus	neuropeptide s receptor	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Schistosoma mansoni	biogenic amine receptor	0.0081	0.7712	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0081	0.7712	1
Brugia malayi	Dopamine receptor protein 1	0.0081	0.7712	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0081	0.7712	0.7712
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0013	0.0439	0.0569
Onchocerca volvulus		0.0081	0.7712	0.5
Echinococcus granulosus	neuropeptide receptor	0.0081	0.7712	1
Brugia malayi	hypothetical protein	0.0081	0.7712	1
Brugia malayi	G-protein coupled receptor	0.0081	0.7712	1
Echinococcus granulosus	voltage gated potassium channel	0.0013	0.0439	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0081	0.7712	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0081	0.7712	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0081	0.7712	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0081	0.7712	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0081	0.7712	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0081	0.7712	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0081	0.7712	0.7712
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0081	0.7712	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.3833	0.497
Schistosoma mansoni	opsin-like receptor	0.0081	0.7712	1
Schistosoma mansoni	neuropeptide receptor	0.0081	0.7712	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0081	0.7712	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0081	0.7712	0.7712
Echinococcus multilocularis	fmrfamide receptor	0.0081	0.7712	1
Schistosoma mansoni	myosin xvIII	0.0081	0.7712	1
Schistosoma mansoni	amine GPCR	0.0081	0.7712	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0081	0.7712	1
Brugia malayi	hypothetical protein	0.0081	0.7712	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0081	0.7712	1
Brugia malayi	hypothetical protein	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Echinococcus multilocularis	serotonin receptor	0.0081	0.7712	1
Onchocerca volvulus		0.0081	0.7712	0.5
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Onchocerca volvulus		0.0081	0.7712	0.5
Brugia malayi	hypothetical protein	0.0081	0.7712	1
Brugia malayi	Dopamine receptor protein 2	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0081	0.7712	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0081	0.7712	1
Brugia malayi	G protein-coupled receptor	0.0081	0.7712	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0081	0.7712	1
Brugia malayi	hypothetical protein	0.0081	0.7712	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0081	0.7712	1
Echinococcus granulosus	serotonin receptor	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Schistosoma mansoni	neuropeptide F-like receptor	0.0081	0.7712	1
Brugia malayi	neuropeptide F receptor	0.0081	0.7712	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.3518	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0081	0.7712	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0081	0.7712	1
Schistosoma mansoni	histamine h1 receptor	0.0081	0.7712	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0081	0.7712	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Schistosoma mansoni	hypothetical protein	0.0081	0.7712	1
Brugia malayi	putative neuropeptide receptor	0.0081	0.7712	1
Echinococcus multilocularis	neuropeptide receptor	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Echinococcus multilocularis	allatostatin A receptor	0.0081	0.7712	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0081	0.7712	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0081	0.7712	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.7712	0.7712
Brugia malayi	hypothetical protein	0.0081	0.7712	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0081	0.7712	1
Onchocerca volvulus		0.0081	0.7712	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0081	0.7712	1
Echinococcus multilocularis	voltage gated potassium channel	0.0013	0.0439	0.0569
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0081	0.7712	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0081	0.7712	1
Echinococcus granulosus	g protein coupled receptor	0.0081	0.7712	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0081	0.7712	1
Echinococcus granulosus	neuropeptides capa receptor	0.0081	0.7712	1
Echinococcus granulosus	neuropeptide receptor A26	0.0081	0.7712	1
Brugia malayi	larval opioid receptor	0.0081	0.7712	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0081	0.7712	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0081	0.7712	1
Brugia malayi	GnHR receptor homolog	0.0081	0.7712	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0081	0.7712	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0081	0.7712	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.83 uM	Inhibition of human ROMK channel-mediated 86Rb+ flux expressed in CHO cells after 35 mins by scintillation counting analysis	ChEMBL.	24075732
IC50 (binding)	= 3.4 uM	Displacement of [35S]-MK499 from human ERG	ChEMBL.	24075732

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2441428

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1791528