TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 421.452 | Formula: C21H23N7O3
H donors: 0 H acceptors: 6 LogP: 2.22 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CCN(CC1)CCc1ccc(cc1)[N+](=O)[O-])Cc1ccc(cc1)n1cnnn1
InChi: 1S/C21H23N7O3/c29-21(15-18-3-5-19(6-4-18)27-16-22-23-24-27)26-13-11-25(12-14-26)10-9-17-1-7-20(8-2-17)28(30)31/h1-8,16H,9-15H2
InChiKey: VWVVYFJIUBMXBZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium inwardly-rectifying channel, subfamily J, member 1	Starlite/ChEMBL	References
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Onchocerca volvulus		0.0023	0.152	0.5
Onchocerca volvulus		0.0023	0.152	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.3518	1
Brugia malayi	putative neuropeptide receptor	0.0023	0.152	0.3965
Brugia malayi	Dopamine receptor	0.0023	0.152	0.3965
Echinococcus granulosus	sex peptide receptor	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Brugia malayi	sulfakinin receptor protein	0.0023	0.152	0.3965
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0023	0.152	0.3965
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.152	0.3558
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0023	0.152	0.3965
Brugia malayi	hypothetical protein	0.0023	0.152	0.3965
Brugia malayi	hypothetical protein	0.0023	0.152	0.3965
Brugia malayi	ORL1-like opioid receptor	0.0023	0.152	0.3965
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0023	0.152	0.3965
Schistosoma mansoni	amine GPCR	0.0023	0.152	0.3558
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0023	0.152	0.3558
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.3518	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.152	0.3965
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.152	0.3558
Echinococcus multilocularis	serotonin receptor	0.0023	0.152	0.3965
Echinococcus multilocularis	somatostatin receptor	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0023	0.152	0.3558
Schistosoma mansoni	opsin-like receptor	0.0023	0.152	0.3558
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0039	0.3202	0.3202
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0023	0.152	0.3965
Brugia malayi	neuropeptide F receptor	0.0023	0.152	0.3965
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Schistosoma mansoni	neuropeptide f receptor 76f	0.0023	0.152	0.3558
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0023	0.152	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0013	0.0439	0.1145
Onchocerca volvulus		0.0023	0.152	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0023	0.152	0.3965
Schistosoma mansoni	growth hormone secretagogue receptor	0.0023	0.152	0.3558
Schistosoma mansoni	amine GPCR	0.0023	0.152	0.3558
Echinococcus granulosus	dro:myosuppressin receptor	0.0023	0.152	0.3965
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0023	0.152	0.3965
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0023	0.152	0.3965
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0023	0.152	0.3558
Brugia malayi	hypothetical protein	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0023	0.152	0.5
Brugia malayi	hypothetical protein	0.0023	0.152	0.3965
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.152	0.3558
Schistosoma mansoni	neuropeptide F-like receptor	0.0023	0.152	0.3558
Brugia malayi	hypothetical protein	0.0023	0.152	0.3965
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0023	0.152	0.3558
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.152	0.3558
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0023	0.152	0.3965
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0023	0.152	0.3558
Echinococcus multilocularis	neuropeptide receptor A26	0.0023	0.152	0.3965
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.152	0.3965
Echinococcus granulosus	fmrfamide receptor	0.0023	0.152	0.3965
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0023	0.152	0.3965
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.152	0.3965
Schistosoma mansoni	opsin-like receptor	0.0023	0.152	0.3558
Brugia malayi	follicle stimulating hormone receptor	0.0023	0.152	0.3965
Echinococcus multilocularis	fmrfamide receptor	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Brugia malayi	hypothetical protein	0.0023	0.152	0.3965
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Echinococcus multilocularis	neuropeptide Y receptor	0.0023	0.152	0.3965
Echinococcus multilocularis	neuropeptides capa receptor	0.0023	0.152	0.3965
Schistosoma mansoni	neuropeptide receptor	0.0023	0.152	0.3558
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Echinococcus granulosus	neuropeptide FF receptor 2	0.0023	0.152	0.3965
Echinococcus granulosus	allatostatin A receptor	0.0023	0.152	0.3965
Echinococcus granulosus	hypothetical protein	0.0023	0.152	0.3965
Brugia malayi	larval opioid receptor	0.0023	0.152	0.3965
Echinococcus multilocularis	neuropeptide s receptor	0.0023	0.152	0.3965
Echinococcus multilocularis	neuropeptide receptor	0.0023	0.152	0.3965
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.152	0.3965
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0023	0.152	0.3965
Echinococcus multilocularis	sex peptide receptor	0.0023	0.152	0.3965
Echinococcus multilocularis	serotonin receptor	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Echinococcus multilocularis	neuropeptide receptor	0.0023	0.152	0.3965
Brugia malayi	GnHR receptor homolog	0.0023	0.152	0.3965
Echinococcus granulosus	g protein coupled receptor	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0023	0.152	0.152
Schistosoma mansoni	amine GPCR	0.0023	0.152	0.3558
Toxoplasma gondii	hypothetical protein	0.0102	1	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Echinococcus granulosus	neuropeptide Y receptor	0.0023	0.152	0.3965
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0013	0.0439	0.1145
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.152	0.3965
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0023	0.152	0.3965
Brugia malayi	hypothetical protein	0.0023	0.152	0.3965
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0023	0.152	0.3558
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0023	0.152	0.3965
Brugia malayi	AKH receptor	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0023	0.152	0.152
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0023	0.152	0.3965
Schistosoma mansoni	biogenic amine receptor	0.0023	0.152	0.3558
Schistosoma mansoni	hypothetical protein	0.0023	0.152	0.3558
Onchocerca volvulus		0.0023	0.152	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0439	0.1028
Brugia malayi	Dopamine receptor protein 2	0.0023	0.152	0.3965
Echinococcus granulosus	serotonin receptor	0.0023	0.152	0.3965
Brugia malayi	G-protein coupled receptor	0.0023	0.152	0.3965
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0439	0.1028
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Echinococcus multilocularis	G protein coupled receptor 139	0.0023	0.152	0.3965
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.3833	1
Echinococcus granulosus	somatostatin receptor	0.0023	0.152	0.3965
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0023	0.152	0.3965
Brugia malayi	hypothetical protein	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Onchocerca volvulus		0.0023	0.152	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Brugia malayi	G protein-coupled receptor F59B2.13	0.0023	0.152	0.3965
Schistosoma mansoni	hypothetical protein	0.0023	0.152	0.3558
Echinococcus multilocularis	g-protein coupled receptor	0.0023	0.152	0.3965
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0023	0.152	0.152
Schistosoma mansoni	amine GPCR	0.0023	0.152	0.3558
Onchocerca volvulus		0.0023	0.152	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.152	0.3965
Schistosoma mansoni	myosin xvIII	0.0023	0.152	0.3558
Echinococcus multilocularis	allatostatin A receptor	0.0023	0.152	0.3965
Brugia malayi	putative neuropeptide receptor NPR1	0.0023	0.152	0.3965
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.152	0.3965
Echinococcus granulosus	voltage gated potassium channel	0.0013	0.0439	0.1145
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0023	0.152	0.3965
Echinococcus granulosus	orexin receptor type 2	0.0023	0.152	0.3965
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.152	0.3965
Onchocerca volvulus		0.0023	0.152	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0023	0.152	0.3558
Onchocerca volvulus		0.0023	0.152	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0023	0.152	0.3965
Echinococcus granulosus	neuropeptide receptor	0.0023	0.152	0.3965
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.152	0.3558
Echinococcus granulosus	7TM GPCR rhodopsin	0.0023	0.152	0.3965
Echinococcus granulosus	g-protein coupled receptor	0.0023	0.152	0.3965
Brugia malayi	hypothetical protein	0.0023	0.152	0.3965
Onchocerca volvulus		0.0023	0.152	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.152	0.3558
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0023	0.152	0.3965
Echinococcus multilocularis	fmrfamide receptor	0.0023	0.152	0.3965
Echinococcus multilocularis	neuropeptides capa receptor	0.0023	0.152	0.3965
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.152	0.3558
Brugia malayi	Serotonin receptor	0.0023	0.152	0.3965
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.152	0.3965
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0023	0.152	0.152
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.152	0.3965
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.152	0.3965
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.152	0.3965
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.152	0.3965
Echinococcus granulosus	neuropeptides capa receptor	0.0023	0.152	0.3965
Onchocerca volvulus		0.0023	0.152	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0023	0.152	0.3965
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.3833	0.3833
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Brugia malayi	hypothetical protein	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0023	0.152	0.3965
Echinococcus granulosus	biogenic amine 5HT receptor	0.0023	0.152	0.3965
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0023	0.152	0.3965
Schistosoma mansoni	histamine h1 receptor	0.0023	0.152	0.3558
Loa Loa (eye worm)	neuropeptide F receptor	0.0023	0.152	0.152
Echinococcus multilocularis	dro:myosuppressin receptor	0.0023	0.152	0.3965
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.152	0.3558
Loa Loa (eye worm)	G-protein coupled receptor	0.0023	0.152	0.152
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Echinococcus granulosus	G protein coupled receptor 139	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Schistosoma mansoni	hypothetical protein	0.0023	0.152	0.3558
Onchocerca volvulus		0.0023	0.152	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.152	0.3558
Echinococcus multilocularis	orexin receptor type 2	0.0023	0.152	0.3965
Onchocerca volvulus		0.0023	0.152	0.5
Onchocerca volvulus		0.0023	0.152	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0023	0.152	0.3558
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0023	0.152	0.3965
Schistosoma mansoni	opsin-like receptor	0.0023	0.152	0.3558
Schistosoma mansoni	neuropeptide F-like receptor	0.0023	0.152	0.3558
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Brugia malayi	G protein-coupled receptor	0.0023	0.152	0.3965
Echinococcus granulosus	neuropeptide Y receptor	0.0023	0.152	0.3965
Schistosoma mansoni	amine GPCR	0.0023	0.152	0.3558
Onchocerca volvulus		0.0023	0.152	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Echinococcus granulosus	neuropeptide receptor A26	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Brugia malayi	RE15519p	0.0023	0.152	0.3965
Brugia malayi	G-protein coupled receptor	0.0023	0.152	0.3965
Onchocerca volvulus		0.0023	0.152	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Echinococcus multilocularis	voltage gated potassium channel	0.0013	0.0439	0.1145
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0023	0.152	0.3558
Loa Loa (eye worm)	neuropeptide F receptor	0.0023	0.152	0.152
Brugia malayi	Serotonin receptor	0.0023	0.152	0.3965
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.152	0.3965
Loa Loa (eye worm)	G-protein coupled receptor	0.0023	0.152	0.152
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Loa Loa (eye worm)	melatonin receptor type 1A	0.0023	0.152	0.152
Schistosoma mansoni	neuropeptide receptor	0.0023	0.152	0.3558
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.152	0.3965
Loa Loa (eye worm)	TYRA-2 protein	0.0023	0.152	0.152
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.152	0.3965
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.4272	1
Schistosoma mansoni	biogenic amine receptor	0.0023	0.152	0.3558
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0023	0.152	0.3558
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Brugia malayi	neuropeptide F receptor	0.0023	0.152	0.3965
Brugia malayi	Dopamine receptor protein 1	0.0023	0.152	0.3965
Echinococcus granulosus	g protein coupled receptor	0.0023	0.152	0.3965
Echinococcus granulosus	neuropeptide receptor	0.0023	0.152	0.3965
Schistosoma mansoni	adenoreceptor	0.0023	0.152	0.3558
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0013	0.0439	0.1145
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0023	0.152	0.3558
Echinococcus granulosus	g protein coupled receptor	0.0023	0.152	0.3965
Brugia malayi	Melatonin receptor type 1A	0.0023	0.152	0.3965
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.152	0.3965
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.152	0.3965
Onchocerca volvulus		0.0023	0.152	0.5
Schistosoma mansoni	neuropeptide receptor	0.0023	0.152	0.3558
Echinococcus multilocularis	neuropeptide Y receptor	0.0023	0.152	0.3965
Echinococcus granulosus	7tm_1 domain containing protein	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Echinococcus granulosus	neuropeptides capa receptor	0.0023	0.152	0.3965
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.152	0.3558
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0023	0.152	0.3558
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0023	0.152	0.3965
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.4272	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.152	0.3965
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0023	0.152	0.152
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0023	0.152	0.3558
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0102	1	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Loa Loa (eye worm)	hypothetical protein	0.0102	1	1
Schistosoma mansoni	hypothetical protein	0.0023	0.152	0.3558
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Schistosoma mansoni	neuropeptide receptor	0.0023	0.152	0.3558
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.3833	1
Loa Loa (eye worm)	hypothetical protein	0.0102	1	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0439	0.0439
Echinococcus granulosus	biogenic amine 5HT receptor	0.0023	0.152	0.3965
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.152	0.3558
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.3833	1
Onchocerca volvulus		0.0023	0.152	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.152	0.3558
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.152	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0023	0.152	0.152
Schistosoma mansoni	biogenic amine receptor	0.0023	0.152	0.3558

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.11 uM	Inhibition of human ROMK channel-mediated 86Rb+ flux expressed in CHO cells after 35 mins by scintillation counting analysis	ChEMBL.	24075732
IC50 (binding)	= 0.16 uM	Displacement of [35S]-MK499 from human ERG	ChEMBL.	24075732

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2441433

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1791533