Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | telomerase reverse transcriptase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Candida albicans | telomerase reverse transcriptase | Get druggable targets OG5_131652 | All targets in OG5_131652 |
Candida albicans | telomerase reverse transcriptase | Get druggable targets OG5_131652 | All targets in OG5_131652 |
Babesia bovis | conserved hypothetical protein | Get druggable targets OG5_131652 | All targets in OG5_131652 |
Theileria parva | hypothetical protein | Get druggable targets OG5_131652 | All targets in OG5_131652 |
Onchocerca volvulus | Telomerase reverse transcriptase homolog | Get druggable targets OG5_131652 | All targets in OG5_131652 |
Brugia malayi | Telomerase reverse transcriptase | Get druggable targets OG5_131652 | All targets in OG5_131652 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0868 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0103 | 0.2592 | 0.5 |
Echinococcus multilocularis | voltage gated potassium channel | 0.001 | 0.0089 | 0.1145 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0036 | 0.0778 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.001 | 0.0089 | 0.1028 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0103 | 0.2592 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0103 | 0.2592 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0103 | 0.2592 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.0778 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0103 | 0.2592 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0103 | 0.2592 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0103 | 0.2592 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.001 | 0.0089 | 0.1145 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.001 | 0.0089 | 0.1145 |
Echinococcus granulosus | voltage gated potassium channel | 0.001 | 0.0089 | 0.1145 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0103 | 0.2592 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.0273 | 0.7216 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.0778 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0033 | 0.0715 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.001 | 0.0089 | 0.0124 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.065 | 0.8354 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0089 | 0.1145 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0033 | 0.0715 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0036 | 0.0778 | 0.1079 |
Schistosoma mansoni | voltage-gated potassium channel | 0.001 | 0.0089 | 0.1028 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0868 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.