Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Zea mays | Protoporphyrinogen IX oxidase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0384 | 0.2287 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.041 | 0.2635 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0384 | 0.2287 | 0.5 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.041 | 0.2635 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.041 | 0.2635 | 0.5 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0963 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.041 | 0.2635 | 0.5 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.041 | 0.2635 | 0.2635 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0384 | 0.2287 | 0.2287 |
Trichomonas vaginalis | CMGC family protein kinase | 0.041 | 0.2635 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.041 | 0.2635 | 0.5 |
Entamoeba histolytica | casein kinase, putative | 0.041 | 0.2635 | 0.5 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.041 | 0.2635 | 0.2635 |
Entamoeba histolytica | protein kinase domain containing protein | 0.041 | 0.2635 | 0.5 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.041 | 0.2635 | 0.5 |
Leishmania major | casein kinase II, putative | 0.041 | 0.2635 | 0.5 |
Trypanosoma brucei | Casein kinase II | 0.041 | 0.2635 | 0.5 |
Brugia malayi | Casein kinase II, alpha chain | 0.041 | 0.2635 | 0.2635 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0384 | 0.2287 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0963 | 1 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0963 | 1 | 1 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0333 | 0.1614 | 0.1614 |
Plasmodium vivax | unspecified product | 0.041 | 0.2635 | 0.5 |
Giardia lamblia | Kinase, CMGC CK2 | 0.041 | 0.2635 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0333 | 0.1614 | 0.5 |
Trypanosoma cruzi | casein kinase II, putative | 0.041 | 0.2635 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.041 | 0.2635 | 0.5 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0963 | 1 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0384 | 0.2287 | 0.2287 |
Schistosoma mansoni | protein kinase | 0.041 | 0.2635 | 0.2635 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.041 | 0.2635 | 0.2635 |
Trichomonas vaginalis | CMGC family protein kinase | 0.041 | 0.2635 | 0.5 |
Onchocerca volvulus | 0.0527 | 0.42 | 0.42 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.041 | 0.2635 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0963 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0963 | 1 | 1 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0963 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.0527 | 0.42 | 0.42 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.38 | Inhibition of protoporphyrinogen IX oxidase in Zea mays cv. Anjou (maize) seedlings homogenates assessed as protoporphyrinogen IX formation by spectrophotometry | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.