Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Zea mays | Protoporphyrinogen IX oxidase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | casein kinase II, putative | 0.0335 | 0.389 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0192 | 0.1957 | 0.5 |
Plasmodium vivax | unspecified product | 0.0335 | 0.389 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0335 | 0.389 | 0.5 |
Trypanosoma brucei | Casein kinase II | 0.0335 | 0.389 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.0335 | 0.389 | 0.5 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0787 | 1 | 1 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0167 | 0.1616 | 0.5 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0335 | 0.389 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0335 | 0.389 | 0.5 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0335 | 0.389 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0335 | 0.389 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0787 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0787 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.0403 | 0.4807 | 0.1501 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0787 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0335 | 0.389 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0335 | 0.389 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0335 | 0.389 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0192 | 0.1957 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0335 | 0.389 | 0.5 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0787 | 1 | 1 |
Leishmania major | casein kinase II, putative | 0.0335 | 0.389 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0335 | 0.389 | 0.2403 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0335 | 0.389 | 0.2403 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0192 | 0.1957 | 0.5 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0787 | 1 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0335 | 0.389 | 0.5 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0335 | 0.389 | 0.2713 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0335 | 0.389 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0787 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0335 | 0.389 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.05 | Inhibition of protoporphyrinogen IX oxidase in Zea mays cv. Anjou (maize) seedlings homogenates assessed as protoporphyrinogen IX formation by spectrophotometry | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.