Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Zea mays | Protoporphyrinogen IX oxidase | Starlite/ChEMBL | No references |
Oryza sativa | Os01g0286600 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.064 | 0.3806 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.064 | 0.3806 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.064 | 0.3806 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.064 | 0.3806 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0384 | 0.1966 | 0.5 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.1502 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.0959 | 0.6101 | 0.3705 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.1502 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.1502 | 1 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.1502 | 1 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0384 | 0.1966 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.064 | 0.3806 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1502 | 1 | 1 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.064 | 0.3806 | 0.2623 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.064 | 0.3806 | 0.5 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.064 | 0.3806 | 0.5 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.1502 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.064 | 0.3806 | 0.229 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.064 | 0.3806 | 0.229 |
Leishmania major | casein kinase II, putative | 0.064 | 0.3806 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.064 | 0.3806 | 0.5 |
Plasmodium vivax | unspecified product | 0.064 | 0.3806 | 0.5 |
Trypanosoma brucei | Casein kinase II | 0.064 | 0.3806 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.064 | 0.3806 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0384 | 0.1966 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.064 | 0.3806 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0333 | 0.1604 | 0.5 |
Giardia lamblia | Kinase, CMGC CK2 | 0.064 | 0.3806 | 0.5 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.1502 | 1 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.064 | 0.3806 | 0.5 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.064 | 0.3806 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.064 | 0.3806 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.3 | Inhibition of Zea mays (maize) protoporphyrinogen IX oxidase | ChEMBL. | No reference |
IC50 (binding) | = 7.41 | Inhibition of Protoporphyrinogen IX oxidase in Zea mays (maize) seedlings assessed as proto-IX formation by fluorescence spectrophotometer | ChEMBL. | No reference |
IC50 (binding) | = 7.6 | Inhibition of protoporphyrinogen IX oxidase in Zea mays cv. DK212MF (maize) seedlings assessed as protoporphyrin IX formation after 5 min by spectrophotometry | ChEMBL. | No reference |
IC50 (binding) | = 7.6 | Inhibition of protoporphyrinogen IX oxidase in Zea mays cv. Anjou (maize) seedlings homogenates assessed as protoporphyrinogen IX formation by spectrophotometry | ChEMBL. | No reference |
IC50 (binding) | = 7.6 | Inhibition of protoporphyrinogen IX oxidase in Zea mays (maize) seed after 5 min by Dixon plot analysis | ChEMBL. | No reference |
IC50 (binding) | = 7.9 | Inhibition of protoporphyrinogen-9 oxidase in Echinochloa esculenta seed after 5 min by Dixon plot analysis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.