Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.1345 | 0.5 | 0.5 |
Loa Loa (eye worm) | lipase | 0.1345 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1345 | 0.5 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1345 | 0.5 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.1345 | 0.5 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.1345 | 0.5 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1345 | 0.5 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1345 | 0.5 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.1345 | 0.5 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1345 | 0.5 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.1345 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 20.56 uM | Antimigratory activity against Homo sapiens (human) MDA-MB-231 cells after 24 to 48 hr by microscopic analysis | ChEMBL. | No reference |
Inhibition (binding) | = 85.44 % | Inhibition of tubulin polymerization in Homo sapiens (human) MDA-MB-231 cells at 10 uM measured every 1 min for 70 min relative to vehicle-treated control | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.