TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 301.168 | Formula: C13H14Cl2N2O2
H donors: 1 H acceptors: 2 LogP: 2.84 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=C1NC(=O)[C@H]2N([C@H]1c1ccccc1Cl)CCC2.Cl
InChi: 1S/C13H13ClN2O2.ClH/c14-9-5-2-1-4-8(9)11-13(18)15-12(17)10-6-3-7-16(10)11;/h1-2,4-5,10-11H,3,6-7H2,(H,15,17,18);1H/t10-,11-;/m0./s1
InChiKey: KEXXWFXZRZAOFX-ACMTZBLWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	transcription factor Dp 1	0.0228	0.0843	0.0916
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0076	0.0084
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.2101	0.9111	1
Trichomonas vaginalis	cyclin B, putative	0.0277	0.1059	0.0768
Echinococcus granulosus	transcription factor Dp 1	0.0228	0.0843	0.0916
Echinococcus granulosus	tyrosine kinase	0.0266	0.1008	0.1097
Loa Loa (eye worm)	hypothetical protein	0.0277	0.1059	0.1162
Echinococcus granulosus	tyrosine kinase	0.0044	0.0029	0.0021
Loa Loa (eye worm)	TK/FER protein kinase	0.0044	0.0029	0.0031
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0394	0.1576	0.0643
Brugia malayi	SH2 domain containing protein	0.0044	0.0029	0.0031
Loa Loa (eye worm)	cyclin domain-containing protein	0.0126	0.0389	0.0427
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0277	0.1059	0.1162
Schistosoma mansoni	tyrosine kinase	0.0294	0.1131	0.1241
Trichomonas vaginalis	cyclins, putative	0.0182	0.0638	0.0285
Brugia malayi	Variant SH3 domain containing protein	0.0061	0.0106	0.0116
Trypanosoma cruzi	cdc2-related kinase 1	0.2101	0.9111	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0255	0.0962	0.1046
Echinococcus multilocularis	geminin	0.0186	0.0656	0.0711
Echinococcus granulosus	c src tyrosine kinase	0.0072	0.0152	0.0157
Onchocerca volvulus		0.005	0.0057	0.0277
Entamoeba histolytica	cyclin, putative	0.0126	0.0389	0.0417
Echinococcus granulosus	cyclin B3 1	0.0126	0.0389	0.0417
Echinococcus multilocularis	cyclins	0.0126	0.0389	0.0417
Echinococcus multilocularis	cyclin dependent kinase 1	0.2101	0.9111	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0294	0.1131	0.1232
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0294	0.1131	0.1232
Schistosoma mansoni	hypothetical protein	0.004	0.0009	0.001
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0294	0.1131	0.1232
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0504	0.0553
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0294	0.1131	0.1232
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0294	0.1131	0.1232
Echinococcus multilocularis	traf and tnf receptor associated protein	0.0363	0.1438	0.157
Echinococcus granulosus	cyclin dependent kinase	0.2101	0.9111	1
Echinococcus granulosus	traf and tnf receptor associated protein	0.0363	0.1438	0.157
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0061	0.0106	0.0106
Brugia malayi	Tyrosine-protein kinase abl-1	0.0072	0.0152	0.0167
Entamoeba histolytica	cell division protein kinase 2, putative	0.2101	0.9111	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0294	0.1131	0.1232
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0394	0.1576	0.1722
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0294	0.1131	0.1232
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.2101	0.9111	1
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0394	0.1576	0.0643
Trypanosoma brucei	cdc2-related kinase 1	0.2101	0.9111	1
Schistosoma mansoni	cyclins	0.0126	0.0389	0.0427
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0294	0.1131	0.1232
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0072	0.0152	0.0157
Mycobacterium ulcerans	haloalkane dehalogenase	0.2302	1	0.5
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0358	0.1414	0.1552
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0277	0.1059	0.1162
Schistosoma mansoni	cyclin B3	0.0126	0.0389	0.0427
Schistosoma mansoni	tyrosine kinase	0.0072	0.0152	0.0167
Entamoeba histolytica	cyclin, putative	0.0277	0.1059	0.1153
Trypanosoma brucei	cdc2-related kinase 3	0.2101	0.9111	1
Echinococcus granulosus	cyclin dependent kinase 1	0.2101	0.9111	1
Schistosoma mansoni	adapter molecule crk	0.0061	0.0106	0.0116
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0126	0.0389	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0029	0.0031
Trypanosoma cruzi	cdc2-related kinase 3	0.2101	0.9111	1
Schistosoma mansoni	serine/threonine protein kinase	0.2101	0.9111	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0266	0.1008	0.1097
Loa Loa (eye worm)	TK/FER protein kinase	0.0044	0.0029	0.0031
Loa Loa (eye worm)	TK/ABL protein kinase	0.0044	0.0029	0.0031
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0316	0.123	0.1341
Echinococcus multilocularis	NCK adaptor protein	0.0061	0.0106	0.0106
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0061	0.0106	0.0116
Loa Loa (eye worm)	TK/FER protein kinase	0.0044	0.0029	0.0031
Trypanosoma cruzi	cdc2-related kinase 1	0.2101	0.9111	1
Echinococcus granulosus	geminin	0.0186	0.0656	0.0711
Schistosoma mansoni	growth factor receptor-bound protein	0.0061	0.0106	0.0116
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0126	0.0389	0.0427
Brugia malayi	Protein kinase domain containing protein	0.0044	0.0029	0.0031
Brugia malayi	SH2 domain containing protein	0.0044	0.0029	0.0031
Brugia malayi	hypothetical protein	0.0044	0.0029	0.0031
Schistosoma mansoni	tyrosine kinase	0.0216	0.0787	0.0864
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0072	0.0152	0.0157
Giardia lamblia	Kinase, CMGC CDK	0.2101	0.9111	1
Plasmodium falciparum	protein kinase 5	0.2101	0.9111	1
Giardia lamblia	Kinase, CMGC CDK	0.2101	0.9111	1
Loa Loa (eye worm)	SRC-1	0.0294	0.1131	0.1241
Schistosoma mansoni	nck2/grb4	0.0061	0.0106	0.0116
Brugia malayi	hypothetical protein	0.004	0.0009	0.001
Schistosoma mansoni	growth factor receptor-bound protein	0.0061	0.0106	0.0116
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.2101	0.9111	1
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0126	0.0389	0.0417
Schistosoma mansoni	hypothetical protein	0.0186	0.0656	0.0721
Brugia malayi	Protein kinase domain containing protein	0.0257	0.0968	0.1062
Trichomonas vaginalis	CMGC family protein kinase	0.2101	0.9111	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0044	0.0029	0.0021
Loa Loa (eye worm)	TK/FAK protein kinase	0.0257	0.0968	0.1062
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0294	0.1131	0.1232
Brugia malayi	cell division control protein 2 homolog	0.2101	0.9111	1
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0394	0.1576	0.1722
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0394	0.1576	0.1722
Trichomonas vaginalis	cyclin A, putative	0.0277	0.1059	0.0768
Entamoeba histolytica	cell division protein kinase 2, putative	0.2101	0.9111	1
Loa Loa (eye worm)	hypothetical protein	0.2078	0.9012	0.9891
Trichomonas vaginalis	cyclins, putative	0.0277	0.1059	0.0768
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.2101	0.9111	1
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0394	0.1576	0.173
Brugia malayi	Variant SH3 domain containing protein	0.0061	0.0106	0.0116
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0294	0.1131	0.1232
Schistosoma mansoni	serine/threonine protein kinase	0.2101	0.9111	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0106	0.0116
Schistosoma mansoni	cyclin B	0.0277	0.1059	0.1162
Echinococcus granulosus	tyrosine protein kinase Srms	0.0044	0.0029	0.0021
Echinococcus multilocularis	tyrosine protein kinase shark	0.0249	0.0935	0.1017
Echinococcus multilocularis	cyclins	0.0126	0.0389	0.0417
Loa Loa (eye worm)	TK/FER protein kinase	0.0044	0.0029	0.0031
Echinococcus multilocularis	tyrosine kinase	0.0044	0.0029	0.0021
Loa Loa (eye worm)	TK/FER protein kinase	0.0044	0.0029	0.0031
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0076	0.0084
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0044	0.0029	0.0021
Echinococcus granulosus	cyclins	0.0126	0.0389	0.0417
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0294	0.1131	0.1232
Trichomonas vaginalis	cyclins, putative	0.0277	0.1059	0.0768
Brugia malayi	protein-tyrosine kinase	0.0266	0.1008	0.1106
Echinococcus multilocularis	cyclin dependent kinase	0.2101	0.9111	1
Trypanosoma cruzi	cdc2-related kinase 3	0.2101	0.9111	1
Echinococcus multilocularis	cyclins	0.0126	0.0389	0.0417
Echinococcus granulosus	tyrosine protein kinase Blk	0.0266	0.1008	0.1097
Echinococcus granulosus	tyrosine protein kinase HCK	0.0232	0.086	0.0935
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.2101	0.9111	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0044	0.0029	0.0031
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0294	0.1131	0.1232
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0076	0.0084
Trichomonas vaginalis	cyclins, putative	0.0277	0.1059	0.0768
Brugia malayi	Protein kinase domain containing protein	0.0044	0.0029	0.0031
Trichomonas vaginalis	cyclin B, putative	0.0277	0.1059	0.0768
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0266	0.1008	0.1097
Trichomonas vaginalis	CMGC family protein kinase	0.2101	0.9111	1
Loa Loa (eye worm)	TK protein kinase	0.0232	0.086	0.0944
Trichomonas vaginalis	cyclin B, putative	0.0277	0.1059	0.0768
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0061	0.0106	0.0116
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0394	0.1576	0.0643
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0266	0.1008	0.1097
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0044	0.0029	0.0021
Brugia malayi	Protein kinase domain containing protein	0.2101	0.9111	1
Echinococcus multilocularis	cyclin b3	0.0126	0.0389	0.0417
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0076	0.0084
Echinococcus multilocularis	cyclins	0.0126	0.0389	0.0417
Trichomonas vaginalis	CMGC family protein kinase	0.2101	0.9111	1
Schistosoma mansoni	tyrosine kinase	0.0254	0.0955	0.1048
Schistosoma mansoni	hypothetical protein	0.0186	0.0656	0.0721
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0072	0.0152	0.0157
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0232	0.086	0.0935
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0044	0.0029	0.0021
Brugia malayi	Protein kinase domain containing protein	0.0044	0.0029	0.0031
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0004	0.0004
Trichomonas vaginalis	cyclins, putative	0.0277	0.1059	0.0768
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0294	0.1131	0.1232
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.2101	0.9111	1
Entamoeba histolytica	cyclin family protein	0.0126	0.0389	0.0417
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0061	0.0106	0.0116
Echinococcus granulosus	cyclin B	0.0277	0.1059	0.1153
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0072	0.0152	0.0167
Echinococcus multilocularis	cyclin B3 1	0.0126	0.0389	0.0417
Echinococcus granulosus	tyrosine protein kinase shark	0.0249	0.0935	0.1017
Entamoeba histolytica	cyclin family protein	0.0126	0.0389	0.0417
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0394	0.1576	0.173
Echinococcus granulosus	cyclins	0.0126	0.0389	0.0417
Trichomonas vaginalis	cyclin B, putative	0.0277	0.1059	0.0768
Loa Loa (eye worm)	TK/FER protein kinase	0.0044	0.0029	0.0031
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0394	0.1576	0.0643
Giardia lamblia	G2/mitotic-specific cyclin B	0.0277	0.1059	0.0768
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0255	0.0962	0.1046
Echinococcus granulosus	NCK adaptor protein	0.0061	0.0106	0.0106
Loa Loa (eye worm)	TK protein kinase	0.0266	0.1008	0.1106
Echinococcus multilocularis	c src tyrosine kinase	0.0072	0.0152	0.0157
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0044	0.0029	0.0021
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0294	0.1131	0.1232
Echinococcus granulosus	cyclin b3	0.0126	0.0389	0.0417
Plasmodium vivax	protein kinase Crk2	0.2101	0.9111	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0044	0.0029	0.0031
Loa Loa (eye worm)	cyclin domain-containing protein	0.0258	0.0976	0.1071
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0009	0.001
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0258	0.0976	0.1071
Echinococcus multilocularis	cyclin dependent kinase 5	0.2101	0.9111	1
Schistosoma mansoni	tyrosine kinase	0.0294	0.1131	0.1241
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0294	0.1131	0.1232
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0363	0.1438	0.1578
Loa Loa (eye worm)	TK/FER protein kinase	0.0044	0.0029	0.0031
Brugia malayi	Protein kinase domain containing protein	0.0044	0.0029	0.0031
Echinococcus granulosus	cyclin dependent kinase 5	0.2101	0.9111	1
Schistosoma mansoni	tyrosine kinase	0.0072	0.0152	0.0167
Echinococcus multilocularis	cyclin B	0.0277	0.1059	0.1153
Echinococcus multilocularis	cyclins	0.0126	0.0389	0.0417
Echinococcus granulosus	protein tyrosine kinase	0.0254	0.0955	0.1039
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0056	0.0082	0.008
Loa Loa (eye worm)	hypothetical protein	0.0277	0.1059	0.1162
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0294	0.1131	0.1232
Echinococcus multilocularis	cyclins	0.0126	0.0389	0.0417
Loa Loa (eye worm)	TK/FER protein kinase	0.0044	0.0029	0.0031
Schistosoma mansoni	tyrosine kinase	0.0249	0.0935	0.1026
Schistosoma mansoni	tyrosine kinase	0.0044	0.0029	0.0031
Echinococcus granulosus	growth factor receptor bound protein 2	0.0061	0.0106	0.0106
Echinococcus multilocularis	cyclin dependent kinase 1	0.2101	0.9111	1
Entamoeba histolytica	protein kinase, putative	0.0232	0.086	0.0935
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0352	0.1391	0.1282
Echinococcus granulosus	cyclins	0.0126	0.0389	0.0417
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.2101	0.9111	1
Brugia malayi	Sex muscle abnormal protein 5	0.0061	0.0106	0.0116
Entamoeba histolytica	protein kinase, putative	0.0056	0.0082	0.008
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0394	0.1576	0.173
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0266	0.1008	0.1097
Onchocerca volvulus		0.0277	0.1059	1
Brugia malayi	Protein kinase domain containing protein	0.0044	0.0029	0.0031
Echinococcus granulosus	cyclins	0.0126	0.0389	0.0417
Echinococcus multilocularis	protein tyrosine kinase	0.0254	0.0955	0.1039
Brugia malayi	SRC-1	0.0294	0.1131	0.1241
Echinococcus granulosus	cyclins	0.0126	0.0389	0.0417
Echinococcus multilocularis	cyclins	0.0126	0.0389	0.0417

Activities

Activity type	Assay description	Source	Reference
Activity (functional)	Anticonvulsant activity in albino mouse assessed as protection against maximal electroshock-induced seizures at 100 mg/kg, ip after 4 hrs	ChEMBL.	24095092
Activity (ADMET)	Neurotoxicity in albino mouse assessed as minimal motor impairment at 100 mg/kg, ip after 0.5 hrs by rotorod test	ChEMBL.	24095092
Activity (functional)	Anticonvulsant activity in albino mouse assessed as protection against subcutaneous metrazole-induced seizures at 100 mg/kg, ip after 1 hr	ChEMBL.	24095092
Activity (functional)	Anticonvulsant activity in albino mouse assessed as protection against maximal electroshock-induced seizures at 100 mg/kg, ip after 0.5 hrs	ChEMBL.	24095092
Activity (functional)	Anticonvulsant activity in albino mouse assessed as protection against subcutaneous metrazole-induced seizures at 100 mg/kg, ip after 4 hrs	ChEMBL.	24095092
Activity (functional)	Anticonvulsant activity in albino mouse assessed as protection against subcutaneous metrazole-induced seizures at 100 mg/kg, ip after 0.5 hrs	ChEMBL.	24095092
Activity (functional)	Anticonvulsant activity in albino mouse assessed as protection against maximal electroshock-induced seizures at 100 mg/kg, ip after 0.25 hrs	ChEMBL.	24095092
Activity (functional)	Anticonvulsant activity in albino mouse assessed as protection against subcutaneous metrazole-induced seizures at 100 mg/kg, ip after 0.25 hrs	ChEMBL.	24095092
Activity (ADMET)	Neurotoxicity in albino mouse assessed as minimal motor impairment at 100 mg/kg, ip after 0.25 hrs by rotorod test	ChEMBL.	24095092
Activity (functional)	Anticonvulsant activity in albino mouse assessed as protection against maximal electroshock-induced seizures at 100 mg/kg, ip after 1 hr	ChEMBL.	24095092
Activity (ADMET)	Neurotoxicity in albino mouse assessed as minimal motor impairment at 100 mg/kg, ip after 4 hrs by rotorod test	ChEMBL.	24095092
Activity (ADMET)	Neurotoxicity in albino mouse assessed as minimal motor impairment at 100 mg/kg, ip after 1 hr by rotorod test	ChEMBL.	24095092
Activity (functional)	Anticonvulsant activity in albino mouse assessed as protection against subcutaneous metrazole-induced seizures at 300 mg/kg, ip after 0.5 hrs	ChEMBL.	24095092

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2442850

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1793447