Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 8 (neutrophil collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 14 (membrane-inserted) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 8 (neutrophil collagenase) | 467 aa | 467 aa | 33.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | SET domain-containing protein | 0.0722 | 1 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase Ez | 0.0722 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0303 | 0.2326 | 0.2326 |
Loa Loa (eye worm) | matrixin family protein | 0.0198 | 0.0404 | 0.0404 |
Schistosoma mansoni | enhancer of zeste ezh | 0.0722 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase E(z) | 0.0722 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0285 | 0.1998 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of human recombinant MMP-7 at 50 uM by fluorescence spectrophotometric analysis relative to control | ChEMBL. | 24028490 | |
Inhibition (binding) | Inhibition of human recombinant MMP-1 catalytic domain at 50 uM by fluorescence spectrophotometric analysis relative to control | ChEMBL. | 24028490 | |
Inhibition (binding) | = 37 % | Inhibition of human recombinant MMP-3 catalytic domain at 50 uM by fluorescence spectrophotometric analysis relative to control | ChEMBL. | 24028490 |
Ki (binding) | = 0.55 uM | Inhibition of human recombinant MMP-2 using MOCAcPLGLA2pr(Dnp)AR-NH2 as substrate by fluorescence spectrophotometric analysis | ChEMBL. | 24028490 |
Ki (binding) | = 12 uM | Inhibition of human recombinant MMP-9 catalytic domain using MOCAcPLGLA2pr(Dnp)AR-NH2 as substrate by fluorescence spectrophotometric analysis | ChEMBL. | 24028490 |
Ki (binding) | = 15 uM | Inhibition of human recombinant MMP-8 catalytic domain using McaKPLGL9(Dpa)AR-NH2 as substrate by fluorescence spectrophotometric analysis | ChEMBL. | 24028490 |
Ki (binding) | = 17 uM | Inhibition of human recombinant MMP-14 catalytic domain using MOCAcPLGLA2pr(Dnp)AR-NH2 as substrate by fluorescence spectrophotometric analysis | ChEMBL. | 24028490 |
T1/2 (ADMET) | = 462 min | Elimination half life in C57Bl/6J mouse plasma assessed as 4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenol at 25 mg/kg, sc | ChEMBL. | 24028490 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.