Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 14 (membrane-inserted) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0125 | 0.3615 | 0.3615 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.5785 | 1 |
Brugia malayi | Matrixin family protein | 0.0063 | 0.1562 | 0.2047 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0125 | 0.3615 | 0.3763 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0125 | 0.3615 | 1 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0248 | 0.7707 | 0.7707 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0802 | 0.1386 |
Echinococcus granulosus | geminin | 0.019 | 0.5785 | 0.5785 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0049 | 0.0049 |
Brugia malayi | Matrixin family protein | 0.024 | 0.7439 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.0802 | 0.1019 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0125 | 0.3615 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0125 | 0.3615 | 0.3615 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0125 | 0.3615 | 0.6248 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0248 | 0.7707 | 0.7707 |
Mycobacterium ulcerans | hydrolase | 0.0077 | 0.202 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.202 | 0.2715 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0125 | 0.3615 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.024 | 0.7439 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0125 | 0.3615 | 0.6248 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0049 | 0.0049 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0125 | 0.3615 | 1 |
Echinococcus multilocularis | geminin | 0.019 | 0.5785 | 0.5785 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0125 | 0.3615 | 0.3615 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0125 | 0.3615 | 1 |
Onchocerca volvulus | 0.009 | 0.244 | 0.1611 | |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1562 | 0.2099 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0125 | 0.3615 | 1 |
Brugia malayi | Matrixin family protein | 0.0063 | 0.1562 | 0.2047 |
Brugia malayi | Matrixin family protein | 0.0063 | 0.1562 | 0.2047 |
Brugia malayi | Matrixin family protein | 0.0063 | 0.1562 | 0.2047 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0125 | 0.3615 | 0.3615 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.5785 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.3615 | 0.486 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.1562 | 0.2099 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0049 | 0.0049 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.014 | 0.4123 | 0.4694 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0049 | 0.0049 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0049 | 0.0084 |
Schistosoma mansoni | hypothetical protein | 0.009 | 0.244 | 0.4218 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0802 | 0.0802 |
Onchocerca volvulus | Matrilysin homolog | 0.0227 | 0.7018 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0802 | 0.0802 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0125 | 0.3615 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0317 | 1 | 1 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0063 | 0.1562 | 0.2099 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0049 | 0.0049 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.01 | 0.2788 | 0.482 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0125 | 0.3615 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0125 | 0.3615 | 1 |
Brugia malayi | Hemopexin family protein | 0.009 | 0.244 | 0.3237 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0125 | 0.3615 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0049 | 0.0065 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0125 | 0.3615 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.4457 | 0.5992 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0077 | 0.202 | 0.2668 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0125 | 0.3615 | 0.5 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0077 | 0.202 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0077 | 0.202 | 0.5528 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0802 | 0.1386 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0125 | 0.3615 | 0.4826 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.015 | 0.4457 | 0.7704 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0049 | 0.0049 |
Plasmodium vivax | RNA helicase-1, putative | 0.0125 | 0.3615 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0125 | 0.3615 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0125 | 0.3615 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.014 | 0.4123 | 0.5542 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 6 % | Inhibition of human recombinant MMP-7 at 50 uM by fluorescence spectrophotometric analysis relative to control | ChEMBL. | 24028490 |
Inhibition (binding) | = 8 % | Inhibition of human recombinant MMP-1 catalytic domain at 50 uM by fluorescence spectrophotometric analysis relative to control | ChEMBL. | 24028490 |
Inhibition (binding) | = 30 % | Inhibition of human recombinant MMP-3 catalytic domain at 50 uM by fluorescence spectrophotometric analysis relative to control | ChEMBL. | 24028490 |
Ki (binding) | Inhibition of human recombinant MMP-8 catalytic domain using McaKPLGL9(Dpa)AR-NH2 as substrate by fluorescence spectrophotometric analysis | ChEMBL. | 24028490 | |
Ki (binding) | = 0.39 uM | Inhibition of human recombinant MMP-2 using MOCAcPLGLA2pr(Dnp)AR-NH2 as substrate by fluorescence spectrophotometric analysis | ChEMBL. | 24028490 |
Ki (binding) | = 10 uM | Inhibition of human recombinant MMP-9 catalytic domain using MOCAcPLGLA2pr(Dnp)AR-NH2 as substrate by fluorescence spectrophotometric analysis | ChEMBL. | 24028490 |
Ki (binding) | = 12 uM | Inhibition of human recombinant MMP-14 catalytic domain using MOCAcPLGLA2pr(Dnp)AR-NH2 as substrate by fluorescence spectrophotometric analysis | ChEMBL. | 24028490 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.