Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3224 | 0.9799 | 0.9706 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3279 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3224 | 0.9799 | 0.9604 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.3279 | 1 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1935 | 0.5128 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.1935 | 0.5128 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3279 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1935 | 0.5128 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.1935 | 0.5128 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.3279 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3224 | 0.9799 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.1935 | 0.5128 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3279 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3279 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3224 | 0.9799 | 0.9706 |
Onchocerca volvulus | 0.3279 | 1 | 0.5 | |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3279 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.3224 | 0.9799 | 0.9706 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 4.212 | Inhibition of BACE (unknown origin) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.