Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.1935 | 0.5128 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.1935 | 0.5128 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.3224 | 0.9799 | 0.9706 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3279 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3224 | 0.9799 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.1935 | 0.5128 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3224 | 0.9799 | 0.9706 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.3279 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.1935 | 0.5128 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3279 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3224 | 0.9799 | 0.9604 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3224 | 0.9799 | 0.9706 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3279 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3279 | 1 | 1 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.1935 | 0.5128 | 0.5 |
Onchocerca volvulus | 0.3279 | 1 | 0.5 | |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3279 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.3279 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 4.212 | Inhibition of BACE (unknown origin) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.