Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | embryonic ectoderm development protein | 0.0101 | 0.1781 | 0.1781 |
Schistosoma mansoni | enhancer of zeste ezh | 0.0505 | 1 | 1 |
Entamoeba histolytica | WD domain containing protein | 0.0013 | 0 | 0.5 |
Toxoplasma gondii | WD domain, G-beta repeat-containing protein | 0.0013 | 0 | 0.5 |
Plasmodium vivax | chromatin assembly factor 1 protein WD40 domain, putative | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | SET domain-containing protein | 0.0505 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 0.6733 | 0.6733 |
Plasmodium falciparum | chromatin assembly factor 1 subunit, putative | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | polycomb protein suz12 A | 0.0345 | 0.6733 | 0.6733 |
Leishmania major | hypothetical protein, conserved | 0.0013 | 0 | 0.5 |
Toxoplasma gondii | RbAp46 | 0.0013 | 0 | 0.5 |
Plasmodium vivax | chromatin assembly factor 1 P55 subunit, putative | 0.0013 | 0 | 0.5 |
Plasmodium vivax | chromatin assembly factor 1 P55 subunit, putative | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | polycomb protein EED | 0.0101 | 0.1781 | 0.1781 |
Plasmodium falciparum | chromatin assembly factor 1 P55 subunit, putative | 0.0013 | 0 | 0.5 |
Brugia malayi | WD domain containing protein | 0.0101 | 0.1781 | 0.045 |
Loa Loa (eye worm) | WD domain-containing protein | 0.0101 | 0.1781 | 0.045 |
Onchocerca volvulus | 0.0081 | 0.1394 | 0.5 | |
Toxoplasma gondii | RbAp48 | 0.0013 | 0 | 0.5 |
Plasmodium falciparum | chromatin assembly factor 1 protein WD40 domain, putative | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase E(z) | 0.0505 | 1 | 1 |
Echinococcus granulosus | polycomb protein suz12 A | 0.0345 | 0.6733 | 0.6733 |
Giardia lamblia | Histone acetyltransferase type B subunit 2 | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase Ez | 0.0505 | 1 | 1 |
Echinococcus multilocularis | polycomb protein EED | 0.0101 | 0.1781 | 0.1781 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
DIZ (functional) | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hr by disk diffusion method | ChEMBL. | No reference | |
DIZ (functional) | Antifungal activity against Saccharomyces cerevisiae TP (3-2) after 24 hr by disk diffusion method | ChEMBL. | No reference | |
DIZ (functional) | Antifungal activity against Candida albicans 16231 after 24 hr by disk diffusion method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.