Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ubiquitin-activating enzyme E1C, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | ectopic membrane ruffles in embryo protein 1 | 0.0063 | 0.0861 | 0.5 |
Trichomonas vaginalis | ubiquitin-activating enzyme E1, putative | 0.0045 | 0.0513 | 0.0513 |
Echinococcus multilocularis | NEDD8 activating enzyme E1 catalytic subunit | 0.0063 | 0.0861 | 0.5 |
Toxoplasma gondii | NEDD8-activating enzyme E1 catalytic subunit | 0.0063 | 0.0861 | 0.5 |
Trypanosoma brucei | nucleoside 2-deoxyribosyltransferase | 0.0523 | 1 | 1 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0063 | 0.0861 | 0.5 |
Trypanosoma cruzi | hypothetical protein | 0.0523 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein | 0.0523 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0523 | 1 | 1 |
Schistosoma mansoni | ubiquitin-activating enzyme E1C | 0.0063 | 0.0861 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0523 | 1 | 1 |
Echinococcus granulosus | NEDD8 activating enzyme E1 catalytic subunit | 0.0063 | 0.0861 | 0.5 |
Brugia malayi | Ectopic membrane ruffles in embryo protein 1 | 0.0063 | 0.0861 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0523 | 1 | 1 |
Plasmodium falciparum | NEDD8-activating enzyme E1 catalytic subunit, putative | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0523 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log relative k' (ADMET) | = 1.03 | HPLC capacity factor (k') (artificial membrane chromatography) | ChEMBL. | 9544216 |
Mean peak APTT (functional) | = 56 | Mean peak APTT value of the compound was evaluated on rats by intracolonic instillation of a 25% aqueous propylene glycol solution of heparin (25 mg/kg) and compound (50 mg/kg). | ChEMBL. | 9544216 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.