Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | beta tubulin | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Echinococcus granulosus | beta tubulin | 0.0064 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0064 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0064 | 1 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0064 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0064 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0064 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0064 | 1 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0064 | 1 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0064 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0064 | 1 | 1 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0064 | 1 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0064 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0064 | 1 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0064 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0064 | 1 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0064 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0064 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0064 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0064 | 1 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0064 | 1 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0064 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0064 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0064 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0064 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Toxoplasma gondii | beta tubulin | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0064 | 1 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0064 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0064 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0064 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0064 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0064 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0064 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0064 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0064 | 1 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0064 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0064 | 1 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0064 | 1 | 1 |
Leishmania major | beta tubulin | 0.0064 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0064 | 1 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.0064 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0064 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 7.8 | Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP accumulation after 1.5 hrs by TR-FRET immunoassay | ChEMBL. | 24140447 |
Kd (functional) | = 7.9 | Antagonist activity at human histamine H3 receptor expressed in CHO cells assessed as inhibition of forskolin/R-alpha-methylhistamine-induced cAMP accumulation after 1.5 hrs by TR-FRET immunoassay | ChEMBL. | 24140447 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.