Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.4587 | 0.6504 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.7053 | 1 |
Echinococcus granulosus | geminin | 0.0174 | 0.7053 | 1 |
Echinococcus multilocularis | Ankyrin | 0.0015 | 0.0005 | 0.0008 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.0118 | 0.4587 | 0.6504 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.4587 | 0.4587 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0074 | 0.2624 | 0.372 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0118 | 0.4587 | 0.6504 |
Trypanosoma cruzi | ion transport protein, putative | 0.01 | 0.3785 | 0.5 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0014 | 0.000000036902 | 0.000000052325 |
Onchocerca volvulus | Netrin receptor homolog | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0074 | 0.2624 | 0.372 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1714 | 0.1714 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0118 | 0.4587 | 0.6504 |
Brugia malayi | Death domain containing protein | 0.0014 | 0.000000036902 | 0.000000036902 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.7053 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1982 | 0.1982 |
Echinococcus granulosus | Ankyrin | 0.0015 | 0.0005 | 0.0008 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0014 | 0.000000036902 | 0.000000052325 |
Trypanosoma cruzi | ion transport protein, putative | 0.01 | 0.3785 | 0.5 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0014 | 0.000000036902 | 0.000000052325 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0112 | 0.4332 | 0.6142 |
Leishmania major | ion transport protein-like protein | 0.01 | 0.3785 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0005 | 0.0005 |
Brugia malayi | Protein kinase domain containing protein | 0.0014 | 0.000000036902 | 0.000000036902 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0015 | 0.0005 | 0.0008 |
Brugia malayi | Uncoordinated protein 44 | 0.0014 | 0.000000036902 | 0.000000036902 |
Echinococcus multilocularis | geminin | 0.0174 | 0.7053 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 7.8 | Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluorescence assay | ChEMBL. | 24063433 |
Efficacy (functional) | = 96 % | Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluorescence assay relative to morphine | ChEMBL. | 24063433 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.