Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Integrase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0134 | 0.801 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0096 | 0.3896 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.3896 | 0.4864 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.3896 | 0.4864 |
Schistosoma mansoni | hypothetical protein | 0.0096 | 0.3896 | 0.3896 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.7039 | 0.7039 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0096 | 0.3896 | 0.3896 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0096 | 0.3896 | 0.3896 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0134 | 0.801 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0096 | 0.3896 | 0.4864 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0096 | 0.3896 | 0.3896 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0096 | 0.3896 | 0.4864 |
Leishmania major | carbonic anhydrase-like protein | 0.0096 | 0.3896 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0096 | 0.3896 | 0.4864 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.3896 | 0.4864 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0134 | 0.801 | 1 |
Toxoplasma gondii | aspartyl protease ASP5 | 0.0116 | 0.609 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0096 | 0.3896 | 0.6397 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0096 | 0.3896 | 0.4864 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0134 | 0.801 | 0.801 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0134 | 0.801 | 1 |
Plasmodium falciparum | plasmepsin V | 0.0139 | 0.8517 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0134 | 0.801 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0153 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0096 | 0.3896 | 0.4574 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0096 | 0.3896 | 0.3896 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0096 | 0.3896 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0096 | 0.3896 | 0.4864 |
Echinococcus multilocularis | carbonic anhydrase | 0.0096 | 0.3896 | 0.4864 |
Echinococcus granulosus | carbonic anhydrase | 0.0096 | 0.3896 | 0.4864 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0096 | 0.3896 | 0.3896 |
Plasmodium vivax | plasmepsin V, putative | 0.0139 | 0.8517 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0096 | 0.3896 | 0.4864 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0134 | 0.801 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0096 | 0.3896 | 0.3896 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0096 | 0.3896 | 0.4864 |
Echinococcus granulosus | carbonic anhydrase | 0.0096 | 0.3896 | 0.4864 |
Echinococcus multilocularis | carbonic anhydrase | 0.0096 | 0.3896 | 0.4864 |
Trypanosoma brucei | RNA helicase, putative | 0.0125 | 0.7039 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3 uM | Inhibition of Human immunodeficiency virus 1 integrase strand transfer activity after 30 mins by polyacrylamide gel electrophoresis | ChEMBL. | 24084160 |
IC50 (binding) | > 20 uM | Inhibition of Human immunodeficiency virus 1 integrase 3'-processing activity after 30 mins by polyacrylamide gel electrophoresis | ChEMBL. | 24084160 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.