Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Desert hedgehog protein | 0.0585 | 0.8448 | 0.8448 |
Trypanosoma brucei | protein kinase, putative | 0.0094 | 0 | 0.5 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0094 | 0 | 0.5 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0094 | 0 | 0.5 |
Echinococcus multilocularis | smoothened | 0.0675 | 1 | 1 |
Onchocerca volvulus | 0.0094 | 0 | 0.5 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0094 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0094 | 0 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0094 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0426 | 0.5715 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0094 | 0 | 0.5 |
Brugia malayi | Hint module family protein | 0.0159 | 0.1119 | 1 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0094 | 0 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0094 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1119 | 0.1147 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0094 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0661 | 0.976 | 1 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0094 | 0 | 0.5 |
Brugia malayi | Hint module family protein | 0.0159 | 0.1119 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1119 | 0.1147 |
Echinococcus multilocularis | hedgehog | 0.0585 | 0.8448 | 0.8448 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.