Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0413 | 0.7401 | 0.7401 |
Onchocerca volvulus | 0.042 | 0.7626 | 0.5 | |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0413 | 0.7401 | 0.7401 |
Mycobacterium ulcerans | hypothetical protein | 0.0248 | 0.2175 | 0.5 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0495 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.02 | 0.0676 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0413 | 0.7401 | 0.7401 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0248 | 0.2175 | 0.5 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.0495 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0495 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.042 | 0.7626 | 0.7626 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.0495 | 1 | 1 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0495 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.042 | 0.7626 | 0.7626 |
Loa Loa (eye worm) | hypothetical protein | 0.0413 | 0.7401 | 0.6772 |
Loa Loa (eye worm) | hypothetical protein | 0.042 | 0.7626 | 0.7051 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0495 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0248 | 0.2175 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0248 | 0.2175 | 0.5 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0495 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0248 | 0.2175 | 0.5 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.0495 | 1 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0467 | 0.9128 | 0.6327 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.042 | 0.7626 | 0.7626 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0413 | 0.7401 | 0.7401 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.042 | 0.7626 | 0.7626 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0467 | 0.9128 | 0.6327 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.