Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.025 | 0.004 | 0.5 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.2045 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0829 | 0.3252 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0423 | 0.1002 | 0.0044 |
Trypanosoma cruzi | pyruvate dehydrogenase (lipoamide) kinase, putative | 0.0715 | 0.262 | 0.1835 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.2045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2045 | 1 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.2045 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.025 | 0.004 | 0.5 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.2045 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.025 | 0.004 | 0.5 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.1931 | 0.9369 | 0.9299 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.1931 | 0.9369 | 0.9299 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0423 | 0.1002 | 0.0044 |
Trypanosoma brucei | pyruvate dehydrogenase (lipoamide) kinase, putative | 0.0715 | 0.262 | 0.1835 |
Onchocerca volvulus | 0.0423 | 0.1002 | 0.5 | |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.2045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0416 | 0.0962 | 0.0962 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0423 | 0.1002 | 0.0044 |
Giardia lamblia | Hypothetical protein | 0.025 | 0.004 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0423 | 0.1002 | 0.0044 |
Leishmania major | pyruvate dehydrogenase (lipoamide) kinase, putative | 0.0715 | 0.262 | 0.1835 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.2045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.1002 | 0.1002 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.2045 | 1 | 1 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.025 | 0.004 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.