Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | cysteine proteinase falcipain 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Plasmodium vivax | vivapain-1 | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium vivax | unspecified product | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium yoelii | cysteine proteinase precursor | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium berghei | berghepain-1 | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium vivax | unspecified product | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium knowlesi | knowpain-1 | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | cathepsin B | cysteine proteinase falcipain 1 | 569 aa | 516 aa | 20.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.1442 | 0.6027 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0134 | 0.0471 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.064 | 0.064 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0079 | 0.0131 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0079 | 0.0079 |
Entamoeba histolytica | protein kinase, putative | 0.0023 | 0.0000000071377 | 0.00000090533 |
Schistosoma mansoni | protein kinase | 0.0023 | 0.0000000071377 | 0.0000000071377 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.0214 | 0.0214 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0079 | 0.0131 |
Leishmania major | protein kinase, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0148 | 0.0148 |
Brugia malayi | Muscleblind-like protein | 0.0174 | 0.064 | 0.064 |
Onchocerca volvulus | 0.0023 | 0.0000000071377 | 1 | |
Trichomonas vaginalis | TKL family protein kinase | 0.0023 | 0.0000000071377 | 0.0000000071377 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0079 | 0.0079 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0023 | 0.0000000071377 | 0.000000011843 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0214 | 0.0214 |
Loa Loa (eye worm) | hypothetical protein | 0.1442 | 0.6027 | 0.6027 |
Giardia lamblia | Protein 21.1 | 0.0023 | 0.0000000071377 | 1 |
Toxoplasma gondii | calcium dependent protein kinase CDPK8 | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.064 | 0.064 |
Trichomonas vaginalis | TKL family protein kinase | 0.0023 | 0.0000000071377 | 0.0000000071377 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.0214 | 0.0214 |
Trichomonas vaginalis | TKL family protein kinase | 0.0023 | 0.0000000071377 | 0.0000000071377 |
Loa Loa (eye worm) | glutaminase | 0.2377 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0079 | 1 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0023 | 0.0000000071377 | 0.000000011843 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.0214 | 0.0356 |
Entamoeba histolytica | protein kinase, putative | 0.0023 | 0.0000000071377 | 0.00000090533 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0214 | 0.0214 |
Leishmania major | hypothetical protein, conserved | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | ankyrin repeat-containing protein, putative | 0.0023 | 0.0000000071377 | 0.0000000071377 |
Echinococcus granulosus | integrin linked protein kinase | 0.0023 | 0.0000000071377 | 0.000000011843 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0079 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.0214 | 0.0214 |
Plasmodium vivax | unspecified product | 0.0134 | 0.0471 | 1 |
Toxoplasma gondii | protein kinase domain-containing protein | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | glutaminase | 0.2377 | 1 | 1 |
Leishmania major | protein kinase, putative | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | glutaminase | 0.2377 | 1 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.2377 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0069 | 0.0069 |
Brugia malayi | Protein kinase domain containing protein | 0.1442 | 0.6027 | 0.6027 |
Trypanosoma cruzi | protein kinase, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0197 | 0.074 | 0.1227 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.1442 | 0.6027 | 0.6027 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0079 | 0.0079 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0214 | 0.0214 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.074 | 0.074 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0214 | 0.0214 |
Toxoplasma gondii | Tyrosine kinase-like (TKL) protein | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0023 | 0 | 0.5 |
Plasmodium vivax | unspecified product | 0.0125 | 0.0433 | 0.9195 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.074 | 0.074 |
Giardia lamblia | Kinase, NEK | 0.0023 | 0.0000000071377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1442 | 0.6027 | 0.6027 |
Trichomonas vaginalis | TKL family protein kinase | 0.0023 | 0.0000000071377 | 0.0000000071377 |
Toxoplasma gondii | Tyrosine kinase-like (TKL) protein | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.0214 | 0.0356 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0023 | 0.0000000071377 | 0.0000000071377 |
Brugia malayi | RNA binding protein | 0.0074 | 0.0214 | 0.0214 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0148 | 0.0148 |
Brugia malayi | integrin-linked kinase | 0.0023 | 0.0000000071377 | 0.0000000071377 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0023 | 0.0000000071377 | 0.0000000071377 |
Echinococcus multilocularis | integrin linked protein kinase | 0.0023 | 0.0000000071377 | 0.000000011843 |
Echinococcus granulosus | muscleblind protein | 0.0174 | 0.064 | 0.1062 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0079 | 1 |
Plasmodium vivax | vivapain-1 | 0.0134 | 0.0471 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.1442 | 0.6027 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0079 | 1 |
Trypanosoma brucei | AGC/RSK family serine/threonine kinase, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0214 | 0.0214 |
Brugia malayi | glutaminase DH11.1 | 0.2377 | 1 | 1 |
Loa Loa (eye worm) | TKL/MLK/HH498 protein kinase | 0.0023 | 0.0000000071377 | 0.0000000071377 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0148 | 0.0148 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0174 | 0.064 | 0.1062 |
Echinococcus multilocularis | muscleblind protein | 0.0174 | 0.064 | 0.1062 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.0214 | 0.0214 |
Toxoplasma gondii | protein kinase | 0.0023 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0069 | 0.0069 |
Trypanosoma brucei | STE/STE11 serine/threonine-protein kinase, putative | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | ankyrin repeat protein | 0.0023 | 0.0000000071377 | 0.00000090533 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.0214 | 0.0214 |
Toxoplasma gondii | STE kinase | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1465 | 0.6126 | 0.6126 |
Trypanosoma brucei | Pseudokinase, putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0197 | 0.074 | 0.1227 |
Schistosoma mansoni | tyrosine kinase | 0.0023 | 0.0000000071377 | 0.0000000071377 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0148 | 0.0148 |
Trypanosoma cruzi | protein kinase, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | TKL/MLK/ILK protein kinase | 0.0023 | 0.0000000071377 | 0.0000000071377 |
Trypanosoma brucei | Flagellum attachment zone protein 20 | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.509 | Inhibition of Plasmodium falciparum W2 cysteine protease | ChEMBL. | No reference |
IC50 (binding) | = 3.1 uM | Inhibition of Plasmodium falciparum W2 cysteine protease | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.