Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hint module family protein | 0.0159 | 0.1119 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0426 | 0.5715 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0094 | 0 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0094 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0094 | 0 | 0.5 |
Onchocerca volvulus | 0.0094 | 0 | 0.5 | |
Giardia lamblia | Kinase, CMGC GSK | 0.0094 | 0 | 0.5 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0094 | 0 | 0.5 |
Echinococcus multilocularis | smoothened | 0.0675 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0094 | 0 | 0.5 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0094 | 0 | 0.5 |
Echinococcus granulosus | Desert hedgehog protein | 0.0585 | 0.8448 | 0.8448 |
Echinococcus multilocularis | hedgehog | 0.0585 | 0.8448 | 0.8448 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1119 | 0.1147 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0661 | 0.976 | 1 |
Brugia malayi | Hint module family protein | 0.0159 | 0.1119 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1119 | 0.1147 |
Giardia lamblia | Kinase, CMGC GSK | 0.0094 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0094 | 0 | 0.5 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0094 | 0 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0094 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.