Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | lipase containing protein, putative | 0.1487 | 1 | 1 |
Entamoeba histolytica | lipase, putative | 0.0028 | 0.0064 | 0.5 |
Trypanosoma brucei | triacylglycerol lipase, putative | 0.0028 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | lipase | 0.1487 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0064 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0028 | 0.0064 | 0.0064 |
Trypanosoma cruzi | lipase domain protein, putative | 0.0028 | 0.0064 | 0.0064 |
Brugia malayi | Lipase family protein | 0.0028 | 0.0064 | 0.0064 |
Trypanosoma cruzi | lipase, putative | 0.0028 | 0.0064 | 0.0064 |
Trypanosoma cruzi | lipase, putative | 0.0028 | 0.0064 | 0.0064 |
Giardia lamblia | Hypothetical protein | 0.0028 | 0.0064 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0028 | 0.0064 | 0.0064 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0028 | 0.0064 | 0.0064 |
Leishmania major | lipase precursor-like protein | 0.0028 | 0.0064 | 0.0064 |
Trypanosoma cruzi | lipase, putative | 0.0028 | 0.0064 | 0.0064 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0019 | 0 | 0.5 |
Giardia lamblia | hypothetical protein | 0.0028 | 0.0064 | 0.5 |
Trypanosoma cruzi | Lipase (class 3), putative | 0.0028 | 0.0064 | 0.0064 |
Toxoplasma gondii | lipase | 0.0028 | 0.0064 | 0.5 |
Trypanosoma cruzi | Triglyceride lipase, putative | 0.0028 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0069 | 0.0069 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0064 | 0.0064 |
Trypanosoma cruzi | lipase, putative | 0.0028 | 0.0064 | 0.0064 |
Leishmania major | lipase, putative | 0.0028 | 0.0064 | 0.0064 |
Trypanosoma cruzi | lipase domain protein, putative | 0.0028 | 0.0064 | 0.0064 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0064 | 0.5 |
Leishmania major | class 3 lipase, putative | 0.0028 | 0.0064 | 0.0064 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0069 | 0.0069 |
Trypanosoma brucei | lipase, putative | 0.0028 | 0.0064 | 0.0064 |
Entamoeba histolytica | lipase, putative | 0.0028 | 0.0064 | 0.5 |
Entamoeba histolytica | lipase, putative | 0.0028 | 0.0064 | 0.5 |
Brugia malayi | Lipase family protein | 0.0028 | 0.0064 | 0.0064 |
Onchocerca volvulus | 0.1487 | 1 | 1 | |
Giardia lamblia | Hypothetical protein | 0.0028 | 0.0064 | 0.5 |
Trypanosoma cruzi | lipase, putative | 0.0028 | 0.0064 | 0.0064 |
Trypanosoma brucei | Triglyceride lipase, putative | 0.0028 | 0.0064 | 0.0064 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0064 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.1487 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0064 | 0.5 |
Trypanosoma brucei | lipase-like protein, putative | 0.0028 | 0.0064 | 0.0064 |
Leishmania major | lipase, putative;with=GeneDB:LinJ31_V3.0860 | 0.0028 | 0.0064 | 0.0064 |
Trypanosoma brucei | lipase domain protein, putative | 0.1487 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0028 | 0.0064 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0028 | 0.0064 | 0.0064 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0064 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.1487 | 1 | 1 |
Toxoplasma gondii | lipase | 0.0028 | 0.0064 | 0.5 |
Giardia lamblia | hypothetical protein | 0.0028 | 0.0064 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0064 | 0.5 |
Trypanosoma cruzi | lipase, putative | 0.0028 | 0.0064 | 0.0064 |
Trypanosoma cruzi | lipase, putative | 0.0028 | 0.0064 | 0.0064 |
Toxoplasma gondii | lipase | 0.0028 | 0.0064 | 0.5 |
Plasmodium falciparum | lipase, putative | 0.0028 | 0.0064 | 0.5 |
Trypanosoma cruzi | lipase-like protein, putative | 0.0028 | 0.0064 | 0.0064 |
Leishmania major | hypothetical protein, unknown function | 0.0028 | 0.0064 | 0.0064 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0028 | 0.0064 | 0.0064 |
Brugia malayi | Lipase family protein | 0.0028 | 0.0064 | 0.0064 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0028 | 0.0064 | 0.0064 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0064 | 0.0064 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0064 | 0.0064 |
Leishmania major | hypothetical protein, unknown function | 0.0028 | 0.0064 | 0.0064 |
Trypanosoma brucei | Lipase (class 3), putative | 0.0028 | 0.0064 | 0.0064 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.1487 | 1 | 1 |
Toxoplasma gondii | lipase | 0.0028 | 0.0064 | 0.5 |
Brugia malayi | Lipase family protein | 0.0028 | 0.0064 | 0.0064 |
Trypanosoma brucei | lipase domain protein, putative | 0.1487 | 1 | 1 |
Loa Loa (eye worm) | lipase | 0.0028 | 0.0064 | 0.0064 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1487 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0028 | 0.0064 | 0.5 |
Leishmania major | lipase domain protein, putative | 0.0028 | 0.0064 | 0.0064 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1487 | 1 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.1487 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0064 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0064 | 0.5 |
Schistosoma mansoni | lipase | 0.0028 | 0.0064 | 0.5 |
Entamoeba histolytica | lipase, putative | 0.0028 | 0.0064 | 0.5 |
Trypanosoma brucei | Triglyceride lipase, putative | 0.0028 | 0.0064 | 0.0064 |
Trypanosoma cruzi | lipase, putative | 0.0028 | 0.0064 | 0.0064 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 256 ug ml-1 | Antimicrobial activity against Candida albicans PTCC 5027 after 24 hr by Alamar blue assay | ChEMBL. | No reference |
MIC (functional) | = 512 ug ml-1 | Antimicrobial activity against Escherichia coli PTCC 1338 after 24 hr by Alamar blue assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.