Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hexose transporter | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.003 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.003 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.003 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter 2A | 0.003 | 0 | 0.5 |
Leishmania major | glucose transporter, lmgt1 | 0.003 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.003 | 0 | 0.5 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0096 | 1 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0096 | 1 | 0.5 |
Plasmodium vivax | hexose transporter | 0.0096 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0096 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.003 | 0 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.003 | 0 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0096 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 1 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.003 | 0 | 0.5 |
Leishmania major | glucose transporter, lmgt2 | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0096 | 1 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0096 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0096 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0096 | 1 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.003 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter 1E | 0.003 | 0 | 0.5 |
Leishmania major | glucose transporter, lmgt3 | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | sugar transporter | 0.0096 | 1 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.003 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.003 | 0 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0096 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.003 | 0 | 0.5 |
Plasmodium falciparum | hexose transporter | 0.0096 | 1 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0096 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0096 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0096 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0096 | 1 | 1 |
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.003 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.07 nM | Binding affinity to human thrombin. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.