Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0117 | 0.0638 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0117 | 0.0638 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0388 | 0.4961 | 1 |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0048 | 0.0364 | 0.1983 |
Leishmania major | DNA topoisomerase ii | 0.0109 | 0.1187 | 0.2393 |
Echinococcus granulosus | DNA topoisomerase 3 beta 1 | 0.0048 | 0.0364 | 0.0364 |
Giardia lamblia | DNA topoisomerase II | 0.0136 | 0.1551 | 1 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0048 | 0.0364 | 0.0734 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0388 | 0.4961 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0157 | 0.1836 | 0.1836 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0048 | 0.0364 | 0.1983 |
Leishmania major | DNA topoisomerase III, putative | 0.0048 | 0.0364 | 0.0734 |
Brugia malayi | GRF zinc finger family protein | 0.0048 | 0.0364 | 0.1983 |
Leishmania major | DNA topoisomerase 1A | 0.0048 | 0.0364 | 0.0734 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0157 | 0.1836 | 1 |
Echinococcus granulosus | lamin | 0.003 | 0.0117 | 0.0117 |
Leishmania major | DNA topoisomerase III, putative | 0.0048 | 0.0364 | 0.0734 |
Schistosoma mansoni | microtubule-associated protein tau | 0.076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1187 | 0.6466 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0109 | 0.1187 | 0.2393 |
Schistosoma mansoni | lamin | 0.003 | 0.0117 | 0.0117 |
Echinococcus granulosus | DNA topoisomerase 3 alpha | 0.0048 | 0.0364 | 0.0364 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0048 | 0.0364 | 0.0734 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0157 | 0.1836 | 1 |
Onchocerca volvulus | 0.0048 | 0.0364 | 0.1436 | |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0157 | 0.1836 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0157 | 0.1836 | 1 |
Echinococcus multilocularis | lamin | 0.003 | 0.0117 | 0.0117 |
Toxoplasma gondii | DNA topoisomerase family protein | 0.0048 | 0.0364 | 0.0734 |
Trypanosoma brucei | DNA topoisomerase IA, putative | 0.0048 | 0.0364 | 0.0734 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0048 | 0.0364 | 0.0414 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0388 | 0.4961 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0157 | 0.1836 | 1 |
Giardia lamblia | DNA topoisomerase III | 0.0048 | 0.0364 | 0.2347 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0157 | 0.1836 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0048 | 0.0364 | 0.0734 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0388 | 0.4961 | 1 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0048 | 0.0364 | 0.0734 |
Wolbachia endosymbiont of Brugia malayi | topoisomerase IA, TopA | 0.0048 | 0.0364 | 0.0414 |
Brugia malayi | DNA topoisomerase III | 0.0048 | 0.0364 | 0.1983 |
Entamoeba histolytica | DNA topoisomerase III, putative | 0.0048 | 0.0364 | 0.1983 |
Schistosoma mansoni | lamin | 0.003 | 0.0117 | 0.0117 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0671 | 0.8791 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0109 | 0.1187 | 0.2393 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0117 | 0.0117 |
Plasmodium falciparum | DNA topoisomerase 3, putative | 0.0048 | 0.0364 | 0.0414 |
Entamoeba histolytica | DNA topoisomerase III, putative | 0.0048 | 0.0364 | 0.1983 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0048 | 0.0364 | 0.1983 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0157 | 0.1836 | 0.2089 |
Mycobacterium ulcerans | DNA topoisomerase I | 0.0048 | 0.0364 | 0.0414 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0157 | 0.1836 | 0.2089 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0671 | 0.8791 | 1 |
Loa Loa (eye worm) | DNA topoisomerase III beta-1 | 0.0048 | 0.0364 | 0.1983 |
Schistosoma mansoni | DNA topoisomerase II | 0.0157 | 0.1836 | 0.1836 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.044 | 0.5666 | 0.6446 |
Echinococcus multilocularis | musashi | 0.003 | 0.0117 | 0.0117 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0157 | 0.1836 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.011 | 0.0598 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0048 | 0.0364 | 0.0364 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0117 | 0.0638 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0157 | 0.1836 | 0.3701 |
Treponema pallidum | DNA topoisomerase I (topA) | 0.0048 | 0.0364 | 0.0414 |
Echinococcus multilocularis | DNA topoisomerase 3 beta 1 | 0.0048 | 0.0364 | 0.0364 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0117 | 0.0117 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0048 | 0.0364 | 0.0734 |
Trypanosoma cruzi | DNA topoisomerase IA, putative | 0.0048 | 0.0364 | 0.0734 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0157 | 0.1836 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.0117 | 0.0117 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0671 | 0.8791 | 1 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0117 | 0.0638 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0109 | 0.1187 | 0.2393 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0157 | 0.1836 | 1 |
Plasmodium vivax | DNA topoisomerase 3, putative | 0.0048 | 0.0364 | 0.0414 |
Giardia lamblia | DNA topoisomerase III | 0.0048 | 0.0364 | 0.2347 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0117 | 0.0117 |
Loa Loa (eye worm) | DNA topoisomerase III | 0.0048 | 0.0364 | 0.1983 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0671 | 0.8791 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1187 | 0.6466 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0117 | 0.0638 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0109 | 0.1187 | 0.2393 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0048 | 0.0364 | 0.0734 |
Echinococcus multilocularis | rho GTPase activating protein 20 | 0.0048 | 0.0364 | 0.0364 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0388 | 0.4961 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0671 | 0.8791 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0231 | 0.284 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0157 | 0.1836 | 0.1836 |
Mycobacterium leprae | Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( | 0.0048 | 0.0364 | 0.1282 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0671 | 0.8791 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.076 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase IA, putative | 0.0048 | 0.0364 | 0.0734 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0671 | 0.8791 | 1 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0048 | 0.0364 | 0.0364 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.