Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0111 | 0.0111 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0386 | 0.5069 | 0.5069 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0168 | 0.2046 | 0.2046 |
Toxoplasma gondii | transitional endoplasmic reticulum ATPase, putative | 0.0243 | 0.3091 | 0.5767 |
Echinococcus granulosus | lamin | 0.0029 | 0.0111 | 0.0111 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0243 | 0.3091 | 0.5767 |
Trichomonas vaginalis | proteasome-activating nucleotidase, putative | 0.0096 | 0.1045 | 0.195 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0386 | 0.5069 | 1 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0111 | 0.0111 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0111 | 0.0111 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0407 | 0.536 | 1 |
Brugia malayi | vesicle-fusing ATPase | 0.0239 | 0.3023 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0111 | 0.0111 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0243 | 0.3091 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0168 | 0.2046 | 0.2046 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0386 | 0.5069 | 1 |
Trypanosoma brucei | Valosin-containing protein | 0.0386 | 0.5069 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0386 | 0.5069 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0386 | 0.5069 | 1 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0111 | 0.0368 |
Brugia malayi | transitional endoplasmic reticulum ATPase TER94, putative | 0.0168 | 0.2046 | 0.6768 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0386 | 0.5069 | 1 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0407 | 0.536 | 1 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0407 | 0.536 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0741 | 1 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0407 | 0.536 | 0.536 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0741 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0111 | 0.0368 |
Trichomonas vaginalis | 26S protease regulatory subunit S10b, putative | 0.0096 | 0.1045 | 0.195 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0111 | 0.0111 |
Giardia lamblia | AAA family ATPase | 0.0243 | 0.3091 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0111 | 0.0111 |
Loa Loa (eye worm) | VCP protein | 0.0168 | 0.2046 | 0.6768 |
Brugia malayi | valosin containing protein | 0.0239 | 0.3023 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0111 | 0.0368 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0239 | 0.3023 | 1 |
Schistosoma mansoni | lamin | 0.0029 | 0.0111 | 0.0111 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0407 | 0.536 | 0.536 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0111 | 0.0368 |
Echinococcus granulosus | transitional endoplasmic reticulum atpase | 0.0407 | 0.536 | 0.536 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0111 | 0.0368 |
Schistosoma mansoni | lamin | 0.0029 | 0.0111 | 0.0111 |
Mycobacterium ulcerans | ATPase | 0.0243 | 0.3091 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0104 | 0.0344 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0386 | 0.5069 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.3023 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 10 % | Phytotoxicity against directly seeded Oryza sativa (rice) seedlings assessed as phytotoxic activity ratings (0- no effect to 5-complete killing rating scale) at 100 g/a measured after 3 weeks post compound treatment under green house conditions | ChEMBL. | 27393589 |
Activity (functional) | = 68 % | Relieving activity against bensulfuron-methyl induced injury to Oryza sativa (rice) assessed as growth rate at 1 uM (Rbv = 46 to 53%) | ChEMBL. | 27393060 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.