Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0377 | 1 | 1 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0064 | 0.0651 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0064 | 0.0651 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.0277 | 0.7019 | 1 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0064 | 0.0651 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0377 | 1 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0167 | 0.3737 | 1 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0121 | 0.2359 | 0.5 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0064 | 0.0651 | 0.1741 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0103 | 0.1838 | 1 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0064 | 0.0651 | 0.5 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0121 | 0.2359 | 0.5 |
Chlamydia trachomatis | biotin carboxylase | 0.0058 | 0.0476 | 0.5 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0167 | 0.3737 | 0.3301 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0167 | 0.3737 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0277 | 0.7019 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0167 | 0.3737 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0064 | 0.0651 | 0.1741 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.0167 | 0.3737 | 0.3301 |
Loa Loa (eye worm) | glutaminase 2 | 0.0277 | 0.7019 | 1 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0167 | 0.3737 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0277 | 0.7019 | 1 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0167 | 0.3737 | 0.3301 |
Schistosoma mansoni | glutaminase | 0.0277 | 0.7019 | 0.6812 |
Trichomonas vaginalis | glutaminase, putative | 0.0277 | 0.7019 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.