Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Arabidopsis thaliana | acetolactate synthase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0157 | 0.4254 | 0.32 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0292 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0157 | 0.4254 | 0.32 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0292 | 1 | 1 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0133 | 0.3236 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0133 | 0.3236 | 1 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0076 | 0.0817 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0155 | 0.4183 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0157 | 0.4254 | 0.32 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0133 | 0.3236 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0076 | 0.0817 | 0.5 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0133 | 0.3236 | 1 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0133 | 0.3236 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0093 | 0.1549 | 0.0145 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0157 | 0.4254 | 0.32 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0133 | 0.3236 | 0.1996 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0157 | 0.4254 | 0.3299 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0133 | 0.3236 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0093 | 0.1549 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.0155 | 0.4183 | 0.3117 |
Mycobacterium ulcerans | hypothetical protein | 0.0133 | 0.3236 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.008 | 0.1005 | 0.0199 |
Schistosoma mansoni | tyrosine kinase | 0.0292 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0155 | 0.4183 | 0.3117 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0076 | 0.0817 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.2414 | 0.1023 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.2414 | 0.1023 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0093 | 0.1549 | 0.0792 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.65 | Inhibition of acetolactate synthase in 6-7 days old etiolated Pisum sativum (pea) shoot | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.