Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1303 | 0.2395 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.3031 | 0.6433 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1303 | 0.2395 | 0.1751 |
Echinococcus granulosus | carbonic anhydrase II | 0.1303 | 0.2395 | 0.1751 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.1602 | 0.3094 | 0.2509 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1303 | 0.2395 | 0.3724 |
Brugia malayi | Matrixin family protein | 0.3031 | 0.6433 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.1527 | 0.2918 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.278 | 0.5847 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 0.0781 | 0.1214 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0682 | 0.0945 | 0.1469 |
Loa Loa (eye worm) | hypothetical protein | 0.1254 | 0.228 | 0.3544 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 0.0781 | 0.1214 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.1527 | 0.2918 | 0.3781 |
Loa Loa (eye worm) | AStacin protease | 0.0427 | 0.0347 | 0.054 |
Echinococcus granulosus | Tolloid protein 1 | 0.0682 | 0.0945 | 0.0178 |
Brugia malayi | Hemopexin family protein | 0.1777 | 0.3504 | 0.4818 |
Toxoplasma gondii | hypothetical protein | 0.0612 | 0.0781 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0612 | 0.0781 | 0.1214 |
Brugia malayi | Matrixin family protein | 0.1254 | 0.228 | 0.2652 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1303 | 0.2395 | 0.5929 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1303 | 0.2395 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0612 | 0.0781 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1303 | 0.2395 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 0.0781 | 0.1214 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1303 | 0.2395 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.1254 | 0.228 | 0.5504 |
Schistosoma mansoni | hypothetical protein | 0.1777 | 0.3504 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0682 | 0.0945 | 0.0604 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1303 | 0.2395 | 0.2857 |
Loa Loa (eye worm) | matrixin family protein | 0.278 | 0.5847 | 0.9089 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.1527 | 0.2918 | 0.5 |
Brugia malayi | Matrixin family protein | 0.1254 | 0.228 | 0.2652 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.4558 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.278 | 0.5847 | 1 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.1254 | 0.228 | 0.3544 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0862 | 0.1364 | 0.2143 |
Leishmania major | carbonic anhydrase-like protein | 0.1303 | 0.2395 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1303 | 0.2395 | 0.3724 |
Mycobacterium ulcerans | hydrolase | 0.1527 | 0.2918 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1254 | 0.228 | 0.3544 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.1602 | 0.3094 | 0.2509 |
Loa Loa (eye worm) | hypothetical protein | 0.1254 | 0.228 | 0.3544 |
Loa Loa (eye worm) | hypothetical protein | 0.1527 | 0.2918 | 0.4536 |
Loa Loa (eye worm) | hypothetical protein | 0.0655 | 0.088 | 0.1369 |
Onchocerca volvulus | 0.1777 | 0.3504 | 0.3431 | |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1303 | 0.2395 | 0.2857 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0682 | 0.0945 | 0.0178 |
Brugia malayi | Matrixin family protein | 0.1254 | 0.228 | 0.2652 |
Brugia malayi | Matrixin family protein | 0.1254 | 0.228 | 0.2652 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 20 ug ml-1 | Inhibition of uninfected H9 lymphocytic cell growth | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.