Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0073 | 0.0314 | 0.0314 |
Echinococcus multilocularis | wd40 repeat | 0.0073 | 0.0314 | 0.0314 |
Echinococcus multilocularis | protein will die slowly | 0.1023 | 1 | 1 |
Echinococcus granulosus | protein will die slowly | 0.1023 | 1 | 1 |
Trichomonas vaginalis | WD repeat domain, putative | 0.1023 | 1 | 1 |
Schistosoma mansoni | retinoblastoma binding protein | 0.0073 | 0.0314 | 0.0314 |
Schistosoma mansoni | hypothetical protein | 0.1023 | 1 | 1 |
Loa Loa (eye worm) | WD40 repeat protein | 0.1023 | 1 | 1 |
Echinococcus granulosus | wd40 repeat | 0.0073 | 0.0314 | 0.0314 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0314 | 0.0314 |
Onchocerca volvulus | 0.1023 | 1 | 0.5 | |
Brugia malayi | Hypothetical WD-repeat protein F21H12.1 in chromosome II | 0.0073 | 0.0314 | 0.0314 |
Plasmodium falciparum | SPRY domain, putative | 0.0042 | 0 | 0.5 |
Trichomonas vaginalis | retinoblastoma binding protein, putative | 0.0073 | 0.0314 | 0.0314 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 500 uM | Cytotoxicity against Homo sapiens (human) HT-29 cells assessed as cell viability after 48 hr by MTT assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.