Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.002 | 0.026 | 0.0327 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0099 | 0.7393 | 0.5 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0091 | 0.6697 | 0.6697 |
Trichomonas vaginalis | AGC family protein kinase | 0.002 | 0.026 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.002 | 0.026 | 0.026 |
Schistosoma mansoni | adenosine kinase | 0.0099 | 0.7393 | 0.7393 |
Trichomonas vaginalis | AGC family protein kinase | 0.002 | 0.026 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.002 | 0.026 | 0.0327 |
Echinococcus granulosus | NDR protein kinase | 0.002 | 0.026 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.002 | 0.026 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0037 | 0.1782 | 0.1782 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.6697 | 0.8417 |
Schistosoma mansoni | serine/threonine protein kinase | 0.002 | 0.026 | 0.026 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0091 | 0.6697 | 0.6697 |
Schistosoma mansoni | serine/threonine protein kinase | 0.002 | 0.026 | 0.026 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0128 | 1 | 1 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.002 | 0.026 | 0.0327 |
Brugia malayi | Protein kinase c protein 2 | 0.0109 | 0.8257 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.002 | 0.026 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.002 | 0.026 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.002 | 0.026 | 0.026 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.002 | 0.026 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.002 | 0.026 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.7393 | 0.9292 |
Echinococcus multilocularis | adenosine kinase | 0.0099 | 0.7393 | 0.7393 |
Brugia malayi | protein kinase C II. | 0.0037 | 0.1782 | 0.1903 |
Schistosoma mansoni | atypical protein kinase C | 0.0034 | 0.152 | 0.152 |
Trichomonas vaginalis | AGC family protein kinase | 0.002 | 0.026 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.026 | 0.0327 |
Entamoeba histolytica | protein kinase, putative | 0.002 | 0.026 | 0.5 |
Leishmania major | adenosine kinase, putative | 0.0099 | 0.7393 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0037 | 0.1782 | 0.1782 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.002 | 0.026 | 0.026 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.002 | 0.026 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.002 | 0.026 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.002 | 0.026 | 0.0327 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.002 | 0.026 | 0.0327 |
Echinococcus granulosus | protein kinase C gamma type | 0.0114 | 0.874 | 0.874 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.002 | 0.026 | 0.026 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0128 | 1 | 1 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.002 | 0.026 | 0.0327 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0091 | 0.6697 | 0.6697 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.002 | 0.026 | 0.026 |
Schistosoma mansoni | serine/threonine protein kinase | 0.002 | 0.026 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.002 | 0.026 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.0034 | 0.152 | 0.152 |
Schistosoma mansoni | serine/threonine kinase | 0.002 | 0.026 | 0.026 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.002 | 0.026 | 0.026 |
Brugia malayi | Adenosine kinase-like | 0.0099 | 0.7393 | 0.892 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0128 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.002 | 0.026 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0114 | 0.874 | 0.874 |
Trypanosoma brucei | adenosine kinase, putative | 0.0099 | 0.7393 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0037 | 0.1782 | 0.1782 |
Entamoeba histolytica | protein kinase, putative | 0.002 | 0.026 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0099 | 0.7393 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.0099 | 0.7393 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.002 | 0.026 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.002 | 0.026 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.0099 | 0.7393 | 0.7393 |
Onchocerca volvulus | 0.0088 | 0.6377 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.7957 | 1 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.002 | 0.026 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.002 | 0.026 | 1 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.002 | 0.026 | 0.0327 |
Echinococcus multilocularis | protein kinase c iota type | 0.0034 | 0.152 | 0.152 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.002 | 0.026 | 0.026 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0095 | 0.6997 | 0.8794 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.002 | 0.026 | 0.026 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0099 | 0.7393 | 1 |
Echinococcus granulosus | adenosine kinase | 0.0099 | 0.7393 | 0.7393 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0037 | 0.1782 | 0.2239 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 54 % | Inhibition of estrone sulfatase at 10 microM in intact MCF-7 cells | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.