Detailed information for compound 1805871

Basic information

Technical information
  • TDR Targets ID: 1805871
  • Name: N,N'-diethyl-6-phenyl-1,3,5-triazine-2,4-diam ine
  • MW: 243.308 | Formula: C13H17N5
  • H donors: 2 H acceptors: 3 LogP: 3 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNc1nc(NCC)nc(n1)c1ccccc1
  • InChi: 1S/C13H17N5/c1-3-14-12-16-11(10-8-6-5-7-9-10)17-13(18-12)15-4-2/h5-9H,3-4H2,1-2H3,(H2,14,15,16,17,18)
  • InChiKey: JORVMOGILHGALE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl-(4-ethylamino-6-phenyl-s-triazin-2-yl)amine
  • 1972-98-1
  • 2,4-BIS(ETHYLAMINO)-6-PHENYL-S-TRIAZINE

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni amine oxidase 0.0062 1 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0062 1 0.5
Schistosoma mansoni voltage-gated potassium channel 0.004 0.5984 0.5984
Echinococcus granulosus lysine specific histone demethylase 1A 0.0062 1 1
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0062 1 0.5
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.5369 0.5369
Loa Loa (eye worm) hypothetical protein 0.0032 0.4485 0.4485
Brugia malayi hypothetical protein 0.0062 1 1
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0062 1 0.5
Echinococcus multilocularis protoporphyrinogen oxidase 0.0062 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0062 1 0.5
Toxoplasma gondii histone lysine-specific demethylase 0.0062 1 0.5
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0062 1 1
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0062 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.4929 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0062 1 0.5
Onchocerca volvulus 0.0062 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0062 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0615 0.0615
Mycobacterium tuberculosis Possible oxidoreductase 0.0062 1 0.5
Mycobacterium ulcerans oxidoreductase 0.0062 1 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0615 0.0615
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.4929 1
Plasmodium vivax hypothetical protein, conserved 0.0062 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0062 1 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0062 1 0.5
Schistosoma mansoni amine oxidase 0.0062 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 1 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0062 1 0.5
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0062 1 0.5
Echinococcus multilocularis 0.0062 1 1
Schistosoma mansoni voltage-gated potassium channel 0.004 0.5984 0.5984
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0062 1 0.5
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0062 1 0.5
Plasmodium falciparum protoporphyrinogen oxidase 0.0062 1 0.5
Mycobacterium ulcerans monoamine oxidase 0.0062 1 0.5
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0062 1 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0062 1 0.5
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.5369 0.5369
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0011 0.0615 0.0615
Plasmodium vivax hypothetical protein, conserved 0.0062 1 0.5
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0615 0.0615
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0062 1 0.5
Echinococcus granulosus lysine specific histone demethylase 1A 0.0062 1 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0062 1 0.5
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0615 0.0615
Mycobacterium ulcerans dehydrogenase 0.0062 1 0.5
Leishmania major UDP-galactopyranose mutase 0.0062 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0062 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 1 1
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0615 0.0615
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.5369 0.5369
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.5369 0.5369
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0062 1 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0062 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.35 Inhibition of photosystem-mediated photosynthetic electron transport in Spinacia oleracea (spinach) leaf thylakoid assessed as reduction of oxygen evolution ChEMBL. No reference
IC50 (binding) = 4.02 Inhibition of photosystem-mediated photosynthetic electron transport in Scenedesmus acutus assessed as reduction of oxygen evolution ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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