Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.023 | 0.0958 | 0.1311 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0474 | 0.8265 | 0.8265 |
Schistosoma mansoni | vesicular amine transporter | 0.0333 | 0.4047 | 0.5538 |
Brugia malayi | hypothetical protein | 0.0333 | 0.4047 | 0.4896 |
Echinococcus multilocularis | roundabout 2 | 0.0532 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0532 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.4047 | 0.4047 |
Echinococcus granulosus | defective proboscis extension response | 0.0333 | 0.4047 | 0.4047 |
Schistosoma mansoni | nephrin | 0.0423 | 0.674 | 0.9224 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.4047 | 0.4047 |
Loa Loa (eye worm) | hypothetical protein | 0.0442 | 0.7307 | 0.7307 |
Echinococcus granulosus | neuroglian | 0.0423 | 0.674 | 0.674 |
Loa Loa (eye worm) | hypothetical protein | 0.0532 | 1 | 1 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0198 | 0 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.0423 | 0.674 | 0.674 |
Echinococcus multilocularis | Immunoglobulin | 0.0333 | 0.4047 | 0.4047 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0333 | 0.4047 | 0.4896 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.4047 | 0.4047 |
Echinococcus granulosus | twitchin | 0.0423 | 0.674 | 0.674 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0333 | 0.4047 | 0.5538 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.4047 | 0.4047 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0442 | 0.7307 | 0.7307 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0333 | 0.4047 | 0.5538 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0333 | 0.4047 | 0.4896 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0333 | 0.4047 | 0.4047 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.4047 | 0.4047 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.4047 | 0.4047 |
Echinococcus multilocularis | Immunoglobulin | 0.0333 | 0.4047 | 0.4047 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0474 | 0.8265 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0442 | 0.7307 | 1 |
Echinococcus granulosus | Immunoglobulin | 0.0333 | 0.4047 | 0.4047 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.