Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | WD repeat containing protein 48 | 0.0411 | 1 | 0.5 |
Echinococcus granulosus | WD repeat containing protein 48 | 0.0411 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0234 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0234 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0411 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 201 uM | Cytotoxicity against Homo sapiens (human) A549 cells after 72 hr by MTT assay | ChEMBL. | No reference |
MIC (functional) | = 8 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 21 days by broth dilution method | ChEMBL. | No reference |
MIC (functional) | = 16 ug ml-1 | Antibacterial activity against Escherichia coli after 18 hr by broth microdilution technique | ChEMBL. | No reference |
MIC (functional) | = 31.25 ug ml-1 | Antifungal activity against Saccharomyces cerevisiae after 18 hr by broth microdilution technique | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.